Scaffolding Biomaterials for Cartilage Regeneration

Table 3

Proteins, drugs, or cytokine embedded in biomimetic scaffolds.

Embedding	Scaffolds	Effect	References
Antiangiogenic drug	Fibrin/hyaluronan	Block host vessels ingrowth and enhance constructs survival rate	Centola et al., 2013 [39]
Parathyroid hormone-related protein	Collagen-silk	Inhibit terminal differentiation of chondrocytes and enhance chondrogenesis	Zhang et al., 2013 [40]
Transforming growth factor-𝛽1	Poly(L-lactide)	Induce an anabolic stimulus on AFCs and mimic the ECM three-dimensional environment of AF tissue	Vadalà et al., 2012 [41]
Cadherin-11	Collagen type II sponges	Promote adhesion of chondrocytes and stimulate chondrogenic differentiation	Dong et al., 2013 [42]

AFCs: annulus fibrosus cells; ECM: extracellular matrix.