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Journal of Nanomaterials
Volume 2014, Article ID 543419, 11 pages
http://dx.doi.org/10.1155/2014/543419
Research Article

Characterization and Biocompatibility of Chitosan Gels with Silver and Gold Nanoparticles

1Doctoral Program in Materials Science and Engineering, Autonomous University of San Luis Potosi, Salvador Nava Avenue s/n, Universitary Campus, 78290 San Luis Potosí, SLP, Mexico
2Master and Doctoral Program in Advanced Dentistry, Faculty of Dentistry, Autonomous University of San Luis Potosi, Salvador Nava Avenue No. 2, Universitary Campus, 78290 San Luis Potosí, SLP, Mexico
3Faculty of Chemistry, Autonomous University of San Luis Potosi, Salvador Nava Avenue No. 6, Universitary Campus, 78290 San Luis Potosí, SLP, Mexico
4Faculty of Science, Autonomous University of San Luis Potosi, Salvador Nava Avenue s/n, Universitary Campus, 78290 San Luis Potosí, SLP, Mexico
5Faculty of Dentistry, Juarez University of Durango State, Predio Canoas s/n, Los Ángeles, 34000 Durango, DGO, Mexico

Received 12 May 2014; Accepted 19 August 2014; Published 15 September 2014

Academic Editor: Ruibing Wang

Copyright © 2014 C. Sámano-Valencia et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The presence of bacterial resistance to antibiotics is a very important issue and the search of new alternatives is necessary. In this work, a combination of chitosan gel with silver or gold nanoparticles was prepared and characterized using thermal, rheology, bactericide, and biocompatibility analyses. ESEM images were also taken to visualize the incorporation of the nanoparticles into the gel matrix. Thermal analysis showed a better thermal stability in the chitosan-gold nanoparticles gels compared to the chitosan-silver nanoparticles gels. Rheology analyses showed that the viscosity of the gels decreased when velocity increased and there were differences in viscosity when silver and gold nanoparticles concentrations change. ESEM images showed the presence of agglomerates of silver and gold nanoparticles into the gel matrix with a good distribution; in some cases the formation of microstructures was found. Bactericide results show that these materials present an antibacterial activity against S. aureus, S. mutans, and E. coli. The biocompatibility test showed neither negative reaction nor wound healing delay after the application of the gels in an in vivo test. The gels with silver and gold nanoparticles could be used to treat wound infections in oral or skin applications.