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Journal of Nanomaterials
Volume 2015 (2015), Article ID 121748, 7 pages
http://dx.doi.org/10.1155/2015/121748
Review Article

Nanomaterials-Based Approaches for the Modulation of Sodium Bicarbonate Cotransporters

Department of Physiology, College of Medicine, Gachon University, 191 Hambakmeoro, Yeonsu-gu, Incheon 406-799, Republic of Korea

Received 1 May 2015; Accepted 6 July 2015

Academic Editor: Yong Ho Kim

Copyright © 2015 Jeong Hee Hong. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

and fluid secretion are major functions of all epithelia, and alterations in secretion by sodium bicarbonate cotransporters are associated with many epithelial diseases, such as renal, ocular, and dental abnormalities. Electrolyte and fluid exits are synergistically mediated by the intracellular second messengers, cAMP and Ca2+, and this raises the possibility that ion transporters are involved in simple secretion and more complicated forms of regulation. Evidence indicates that transport is regulated by the assemblage of Na+- cotransporters (NBCs) into complexes by multiple regulatory factors. Recently the specific regulatory functions of factors that interact with NBCe1, especially NBCe1-B, have been elucidated. In this review, I focus on the structural characteristics of electrogenic NBCe1, pathophysiology of NBCe1, and molecular mechanisms responsible for transporter regulation. Moreover I propose the possibility to apply nanomaterials combined with regulatory factors for modulating the activity of NBC transporters as a potential development of therapeutic drug.