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Journal of Nanomaterials
Volume 2015, Article ID 216375, 13 pages
http://dx.doi.org/10.1155/2015/216375
Review Article

Nanosuspension Technologies for Delivery of Poorly Soluble Drugs

1Mawson Institute, University of South Australia, Mawson Lakes, Adelaide, SA 5095, Australia
2School of Engineering, University of South Australia, Mawson Lakes, Adelaide, SA 5095, Australia
3Ian Wark Research Institute, University of South Australia, Mawson Lakes, Adelaide, SA 5095, Adelaide, Australia

Received 15 August 2014; Accepted 15 October 2014

Academic Editor: Haifeng Chen

Copyright © 2015 Roya Yadollahi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Poor aqueous solubility of some drug molecules is a major problem in drug formulation. Drug nanosuspensions emerged as one solution to delivering such hydrophobic drugs. Scaling down to nanoparticles enhances drug aqueous solubility and bioavailability by increasing drug surface area that comes into contact with biological media. Nanosuspensions that have attracted particular attention are those sterically stabilised by steric polymers such as polyethylene glycol (PEG) with a typical size range of 10–100 nm. These nanoparticles are capable of accumulating in targeted areas such as cancer tissues and infarct zones with minimal damage to healthy tissues. Nanosuspensions are often prepared by commercially available methods such as high pressure homogenization, media milling, emulsification, and melt emulsification. Solidification and surface modification methods are post-processing techniques used to add particular properties for advanced therapies. In this review, we firstly describe preparation methods for nanosuspensions. Secondly, we highlight typical characterization techniques. Finally, we describe several practical application of applications for drug delivery design and different administration routes such as parenteral, pulmonary, oral, and ocular.