Table of Contents Author Guidelines Submit a Manuscript
Journal of Nanomaterials
Volume 2015, Article ID 261492, 8 pages
http://dx.doi.org/10.1155/2015/261492
Research Article

In Vivo Osteogenesis of Vancomycin Loaded Nanohydroxyapatite/Collagen/Calcium Sulfate Composite for Treating Infectious Bone Defect Induced by Chronic Osteomyelitis

1College of Mechanics, Taiyuan University of Technology, Taiyuan 030024, China
2Zhengzhou Orthopedics Hospital, Zhengzhou 450052, China
3National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou 215123, China
4State Key Laboratory of New Ceramics and Fine Processing, Department of Materials Science and Engineering, Tsinghua University, Beijing 100084, China

Received 31 August 2014; Accepted 24 October 2014

Academic Editor: Xiaoming Li

Copyright © 2015 Xiaojie Lian et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. X. M. Li, C. A. van Blitterswijk, Q. L. Feng, F. Z. Cui, and F. Watari, “The effect of calcium phosphate microstructure on bone-related cells in vitro,” Biomaterials, vol. 29, no. 23, pp. 3306–3316, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. X. M. Li, H. F. Liu, X. F. Niu et al., “Osteogenic differentiation of human adipose-derived stem cells induced by osteoinductive calcium phosphate ceramics,” Journal of Biomedical Materials Research Part B: Applied Biomaterials, vol. 97, no. 1, pp. 10–19, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. X. M. Li, Y. Huang, L. S. Zheng et al., “Effect of substrate stiffness on the functions of rat bone marrow and adipose tissue derived mesenchymal stem cells in vitro,” Journal of Biomedical Materials Research Part A, vol. 102, no. 4, pp. 1092–1101, 2014. View at Publisher · View at Google Scholar · View at Scopus
  4. C. L. Nelson, S. G. Hickmon, and B. H. Harrison, “Elution characteristics of gentamicin-PMMA beads after implantation in humans,” Orthopedics, vol. 17, no. 5, pp. 415–416, 1994. View at Google Scholar · View at Scopus
  5. S. Deb, R. Doiron, L. DiSilvio, S. Punyani, and H. Singh, “PMMA bone cement containing a quaternary amine comonomer with potential antibacterial properties,” Journal of Biomedical Materials Research B: Applied Biomaterials, vol. 85, no. 1, pp. 130–139, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. D. Neut, O. S. Kluin, J. Thompson, H. C. van der Mei, and H. J. Busscher, “Gentamicin release from commercially-available gentamicin-loaded PMMA bone cements in a prosthesis-related interfacial gap model and their antibacterial efficacy,” BMC Musculoskeletal Disorders, vol. 11, article 258, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. H. L. Tan, W. T. Lin, and T. T. Tang, “The use of antimicrobial-impregnated PMMA to manage periprosthetic infections: controversial issues and the latest developments,” International Journal of Artificial Organs, vol. 35, no. 10, pp. 832–839, 2012. View at Publisher · View at Google Scholar · View at Scopus
  8. S. G. Yan, X. Z. Cai, W. Q. Yan, X. S. Dai, and H. B. Wu, “Continuous wave ultrasound enhances vancomycin release and antimicrobial efficacy of antibiotic-loaded acrylic bone cement in vitro and in vivo,” Journal of Biomedical Materials Research B: Applied Biomaterials, vol. 82, no. 1, pp. 57–64, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. Z. P. Xie, X. Liu, W. T. Jia, C. Q. Zhang, W. H. Huang, and J. Q. Wang, “Treatment of osteomyelitis and repair of bone defect by degradable bioactive borate glass releasing vancomycin,” Journal of Controlled Release, vol. 139, no. 2, pp. 118–126, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. M. Larsson, A. Bergstrand, L. Mesiah, C. Van Vooren, and A. Larsson, “Nanocomposites of polyacrylic acid nanogels and biodegradable polyhydroxybutyrate for bone regeneration and drug delivery,” Journal of Nanomaterials, vol. 2014, Article ID 371307, 9 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  11. X. Lian, H. Liu, X. Wang, S. Xu, F. Cui, and X. Bai, “Antibacterial and biocompatible properties of vancomycin-loaded nano-hydroxyapatite/collagen/poly (lactic acid) bone substitute,” Progress in Natural Science: Materials International, vol. 23, no. 6, pp. 549–556, 2013. View at Publisher · View at Google Scholar · View at Scopus
  12. M.-P. Ginebra, C. Canal, M. Espanol, D. Pastorino, and E. B. Montufar, “Calcium phosphate cements as drug delivery materials,” Advanced Drug Delivery Reviews, vol. 64, no. 12, pp. 1090–1110, 2012. View at Publisher · View at Google Scholar · View at Scopus
  13. U. Joosten, A. Joist, G. Gosheger, U. Liljenqvist, B. Brandt, and C. Von Eiff, “Effectiveness of hydroxyapatite-vancomycin bone cement in the treatment of Staphylococcus aureus induced chronic osteomyelitis,” Biomaterials, vol. 26, no. 25, pp. 5251–5258, 2005. View at Publisher · View at Google Scholar · View at Scopus
  14. H. A. Doty, M. R. Leedy, H. S. Courtney, W. O. Haggard, and J. D. Bumgardner, “Composite chitosan and calcium sulfate scaffold for dual delivery of vancomycin and recombinant human bone morphogenetic protein-2,” Journal of Materials Science: Materials in Medicine, vol. 25, no. 6, pp. 1449–1459, 2014. View at Publisher · View at Google Scholar · View at Scopus
  15. M. V. Thomas and D. A. Puleo, “Calcium sulfate: properties and clinical applications,” Journal of Biomedical Materials Research Part B: Applied Biomaterials, vol. 88, no. 2, pp. 597–610, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. D. Stubbs, M. Deakin, P. Chapman-Sheath et al., “In vivo evaluation of resorbable bone graft substitutes in a rabbit tibial defect model,” Biomaterials, vol. 25, no. 20, pp. 5037–5044, 2004. View at Publisher · View at Google Scholar · View at Scopus
  17. G. Orsini, J. Ricci, A. Scarano et al., “Bone-defect healing with calcium-sulfate particles and cement: an experimental study in rabbit,” Journal of Biomedical Materials Research Part B: Applied Biomaterials, vol. 68, no. 2, pp. 199–208, 2004. View at Google Scholar · View at Scopus
  18. Z. G. Huan and J. Chang, “Self-setting properties and in vitro bioactivity of calcium sulfate hemihydrate-tricalcium silicate composite bone cements,” Acta Biomaterialia, vol. 3, no. 6, pp. 952–960, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. P. Wang, E.-J. Lee, C.-S. Park et al., “Calcium sulfate hemihydrate powders with a controlled morphology for use as bone cement,” Journal of the American Ceramic Society, vol. 91, no. 6, pp. 2039–2042, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. C. Du, F. Z. Cui, X. D. Zhu, and K. De Groot, “Three-dimensional nano-HAp/collagen matrix loading with osteogenic cells in organ culture,” Journal of Biomedical Materials Research, vol. 44, no. 4, pp. 407–415, 1999. View at Publisher · View at Google Scholar · View at Scopus
  21. F.-Z. Cui, Y. Li, and J. Ge, “Self-assembly of mineralized collagen composites,” Materials Science and Engineering R: Reports, vol. 57, no. 1–6, pp. 1–27, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. C. Du, F. Z. Cui, W. Zhang, Q. L. Feng, X. D. Zhu, and K. de Groot, “Formation of calcium phosphate/collagen composites through mineralization of collagen matrix,” Journal of Biomedical Materials Research, vol. 50, no. 4, pp. 518–527, 2000. View at Publisher · View at Google Scholar · View at Scopus
  23. S. S. Liao, F. Z. Cui, W. Zhang, and Q. L. Feng, “Hierarchically biomimetic bone scaffold materials: nano-HA/collagen/PLA composite,” Journal of Biomedical Materials Research Part B: Applied Biomaterials, vol. 69, no. 2, pp. 158–165, 2004. View at Google Scholar · View at Scopus
  24. S. S. Liao and F.-Z. Cui, “In vitro and in vivo degradation of mineralized collagen-based composite scaffold: nanohydroxyapatite/collagen/poly(L-lactide),” Tissue Engineering, vol. 10, no. 1-2, pp. 73–80, 2004. View at Publisher · View at Google Scholar · View at Scopus
  25. Z. Chen, H. Liu, X. Liu, and F.-Z. Cui, “Injectable calcium sulfate/mineralized collagen-based bone repair materials with regulable self-setting properties,” Journal of Biomedical Materials Research Part A, vol. 99, no. 4, pp. 554–563, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. X. M. Li, H. F. Liu, X. F. Niu et al., “The use of carbon nanotubes to induce osteogenic differentiation of human adipose-derived MSCs in vitro and ectopic bone formation in vivo,” Biomaterials, vol. 33, no. 19, pp. 4818–4827, 2012. View at Publisher · View at Google Scholar · View at Scopus
  27. X. Li, H. Gao, M. Uo et al., “Maturation of osteoblast-like SaoS2 induced by carbon nanotubes,” Biomedical Materials, vol. 4, no. 1, Article ID 015005, 2009. View at Publisher · View at Google Scholar · View at Scopus
  28. C. Du, F. Z. Cui, Q. L. Feng, X. D. Zhu, and K. De Groot, “Tissue response to nano-hydroxyapatite/collagen composite implants in marrow cavity,” Journal of Biomedical Materials Research, vol. 42, no. 4, pp. 540–548, 1998. View at Google Scholar · View at Scopus
  29. X. M. Li, L. Wang, Y. B. Fan, Q. L. Feng, F.-Z. Cui, and F. Watari, “Nanostructured scaffolds for bone tissue engineering,” Journal of Biomedical Materials Research Part A, vol. 101, no. 8, pp. 2424–2435, 2013. View at Publisher · View at Google Scholar · View at Scopus
  30. Z. Chen, H. Liu, X. Liu et al., “Improved workability of injectable calcium sulfate bone cement by regulation of self-setting properties,” Materials Science and Engineering C, vol. 33, no. 3, pp. 1048–1053, 2013. View at Publisher · View at Google Scholar · View at Scopus
  31. X. Lian, X. Wang, and F. Cui, “In vitro antibacterial properties of vancomycin-loaded nano-hydroxyapatite/collagen/ calcium sulfate hemihydrates (VCM/nHAC/CSH) bone substitute,” Materials Science Forum: Advances in Functional and Electronic Materials, vol. 745-746, pp. 6–12, 2013. View at Publisher · View at Google Scholar · View at Scopus
  32. W. Zhang, S. S. Liao, and F. Z. Cui, “Hierarchical self-assembly of nano-fibrils in mineralized collagen,” Chemistry of Materials, vol. 15, no. 16, pp. 3221–3226, 2003. View at Publisher · View at Google Scholar · View at Scopus
  33. M. A. Rauschmann, T. A. Wichelhaus, V. Stirnal et al., “Nanocrystalline hydroxyapatite and calcium sulphate as biodegradable composite carrier material for local delivery of antibiotics in bone infections,” Biomaterials, vol. 26, no. 15, pp. 2677–2684, 2005. View at Publisher · View at Google Scholar · View at Scopus
  34. X. M. Li, Q. L. Feng, X. H. Liu, W. Dong, and F. Z. Cui, “Collagen-based implants reinforced by chitin fibres in a goat shank bone defect model,” Biomaterials, vol. 27, no. 9, pp. 1917–1923, 2006. View at Publisher · View at Google Scholar · View at Scopus
  35. C. S. Ciobanu, C. L. Popa, and D. Predoi, “Sm:HAp nanopowders present antibacterial activity against Enterococcus faecalis,” Journal of Nanomaterials, vol. 2014, Article ID 780686, 9 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus