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Journal of Nanomaterials
Volume 2015 (2015), Article ID 367964, 9 pages
http://dx.doi.org/10.1155/2015/367964
Research Article

Electrospinning Preparation of Timosaponin B-II-Loaded PLLA Nanofibers and Their Antitumor Recurrence Activities In Vivo

1Department of General Surgery, 454th Hospital of PLA, Najing 210002, China
2Department of Pharmacy, 454th Hospital of PLA, Najing 210002, China
3Department of Pharmacy, Shanghai Changzheng Hospital, 415 Fengyang Road, Shanghai 200003, China
4Department of Pharmaceutical Science & Technology, College of Chemistry and Biology, Donghua University, 2999 North Renmin Road, Shanghai 201620, China

Received 30 June 2014; Revised 11 September 2014; Accepted 15 September 2014

Academic Editor: Fujuan Liu

Copyright © 2015 Zhonghua Huo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. R. Beil and L. M. Wein, “Sequencing surgery, radiotherapy and chemotherapy: insights from a mathematical analysis,” Breast Cancer Research and Treatment, vol. 74, no. 3, pp. 279–286, 2002. View at Publisher · View at Google Scholar · View at Scopus
  2. B. A. Pockaj and R. J. Gray, “Current surgery for breast cancer,” Future Oncology, vol. 5, no. 4, pp. 465–479, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. P. Bouchard and J. Efron, “Management of recurrent rectal cancer,” Annals of Surgical Oncology, vol. 17, no. 5, pp. 1343–1356, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. X. Luo, C. Xie, H. Wang, C. Liu, S. Yan, and X. Li, “Antitumor activities of emulsion electrospun fibers with core loading of hydroxycamptothecin via intratumoral implantation,” International Journal of Pharmaceutics, vol. 425, no. 1-2, pp. 19–28, 2012. View at Publisher · View at Google Scholar · View at Scopus
  5. N. Wang, Y. Feng, M. Zhu, F.-M. Siu, K.-M. Ng, and C.-M. Che, “A novel mechanism of XIAP degradation induced by timosaponin AIII in hepatocellular carcinoma,” Biochimica et Biophysica Acta—Molecular Cell Research, vol. 1833, no. 12, pp. 2890–2899, 2013. View at Publisher · View at Google Scholar · View at Scopus
  6. C. Guo, L. Li, X. Yang et al., “Protective effects of timosaponin B-II on high glucose-induced apoptosis in human umbilical vein endothelial cells,” Environmental Toxicology and Pharmacology, vol. 37, no. 1, pp. 37–44, 2014. View at Publisher · View at Google Scholar · View at Scopus
  7. T.-J. Li, Y. Qiu, P.-Y. Yang, Y.-C. Rui, and W.-S. Chen, “Timosaponin B-II improves memory and learning dysfunction induced by cerebral ischemia in rats,” Neuroscience Letters, vol. 421, no. 2, pp. 147–151, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. S. Cheng, Y. Du, B. Ma, and D. Tan, “Total synthesis of a furostan saponin, timosaponin BII,” Organic and Biomolecular Chemistry, vol. 7, no. 15, pp. 3112–3118, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. F. Cai, L. Sun, S. Gao, Y. Yang, Q. Yang, and W. Chen, “A rapid and sensitive liquid chromatography-tandem mass spectrometric method for the determination of timosaponin B-II in blood plasma and a study of the pharmacokinetics of saponin in the rat,” Journal of Pharmaceutical and Biomedical Analysis, vol. 48, no. 5, pp. 1411–1416, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. Z. Liu, X. Dong, X. Ding et al., “Comparative pharmacokinetics of timosaponin B-II and timosaponin A-III after oral administration of Zhimu-Baihe herb-pair, Zhimu extract, free timosaponin B-II and free timosaponin A-III to rats,” Journal of Chromatography B, vol. 926, pp. 28–35, 2013. View at Publisher · View at Google Scholar · View at Scopus
  11. F. W. King, S. Fong, C. Griffin et al., “Timosaponin AIII is preferentially cytotoxic to tumor cells through inhibition of mTOR and induction of ER stress,” PLoS ONE, vol. 4, no. 9, Article ID e7283, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. A. Rogina, “Electrospinning process: versatile preparation method for biodegradable and natural polymers and biocomposite systems applied in tissue engineering and drug delivery,” Applied Surface Science, vol. 296, pp. 221–230, 2014. View at Publisher · View at Google Scholar · View at Scopus
  13. T. J. Sill and H. A. von Recum, “Electrospinning: applications in drug delivery and tissue engineering,” Biomaterials, vol. 29, no. 13, pp. 1989–2006, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. X. Luo, G. Xu, H. Song et al., “Promoted antitumor activities of acid-labile electrospun fibers loaded with hydroxycamptothecin via intratumoral implantation,” European Journal of Pharmaceutics and Biopharmaceutics, vol. 82, no. 3, pp. 545–553, 2012. View at Publisher · View at Google Scholar · View at Scopus
  15. B. D. Weinberg, E. Blanco, and J. Gao, “Polymer implants for intratumoral drug delivery and cancer therapy,” Journal of Pharmaceutical Sciences, vol. 97, no. 5, pp. 1681–1702, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. P. Chen, Q.-S. Wu, Y.-P. Ding, M. Chu, Z.-M. Huang, and W. Hu, “A controlled release system of titanocene dichloride by electrospun fiber and its antitumor activity in vitro,” European Journal of Pharmaceutics and Biopharmaceutics, vol. 76, no. 3, pp. 413–420, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. S. Huang, X. Kang, Z. Cheng, P. Ma, Y. Jia, and J. Lin, “Electrospinning preparation and drug delivery properties of Eu3+/Tb3+doped mesoporous bioactive glass nanofibers,” Journal of Colloid and Interface Science, vol. 387, pp. 285–291, 2012. View at Publisher · View at Google Scholar
  18. Y.-H. Liao, C.-C. Lin, T.-C. Li, and J.-G. Lin, “Utilization pattern of traditional Chinese medicine for liver cancer patients in Taiwan,” BMC Complementary and Alternative Medicine, vol. 12, article 146, 2012. View at Publisher · View at Google Scholar · View at Scopus
  19. A. Jemal, R. Siegel, E. Ward et al., “Cancer statistics, 2006,” CA: A Cancer Journal for Clinicians, vol. 56, no. 2, pp. 106–130, 2006. View at Publisher · View at Google Scholar · View at Scopus
  20. B. H. Yang, J. L. Xia, L. W. Huang et al., “Changes of clinical aspect of PLC in China during the past 30 yearsdcontrol study for 3, 250 cases with PLC,” National Medical Journal of China, vol. 83, pp. 1053–1057, 2003. View at Google Scholar
  21. P. Wang, Z. Q. Meng, Z. Chen et al., “Diagnostic value and complications of fine needle aspiration for primary liver cancer and its influence on the treatment outcome-a study based on 3011 patients in China,” European Journal of Surgical Oncology, vol. 34, no. 5, pp. 541–546, 2008. View at Publisher · View at Google Scholar · View at Scopus
  22. M. A. Canosa, S. P. Fernández, J. Q. Fandiño et al., “Surgical treatment of liver cancer: experience of the A Coruña UHC (Spain),” Cirugía Española, vol. 89, no. 4, pp. 223–229, 2011. View at Publisher · View at Google Scholar · View at Scopus
  23. B. Aussilhou, Y. Panis, A. Alves, C. Nicco, and D. Klatzmann, “Tumor recurrence after partial hepatectomy for liver metastases in rats: prevention by in vivo injection of irradiated cancer cells expressing GMCSF and IL-12,” Journal of Surgical Research, vol. 149, no. 2, pp. 184–191, 2008. View at Publisher · View at Google Scholar · View at Scopus