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Journal of Nanomaterials
Volume 2015, Article ID 381836, 6 pages
Research Article

Preparation of Mesoporous Silica-Supported Chiral Amino Alcohols for the Enantioselective Addition of Diethylzinc to Aldehyde and Asymmetric Transfer Hydrogenation to Ketones

1Faculty of Industrial Sciences and Technology, Universiti Malaysia Pahang, 26300 Gambang, Kuantan, Malaysia
2Nanotechnology and Catalysis Research Centre (NanoCat), University of Malaya, Level 3, Block A, IPS Building, 50603 Kuala Lumpur, Malaysia

Received 10 October 2014; Revised 17 December 2014; Accepted 18 December 2014

Academic Editor: Bo Song

Copyright © 2015 Shaheen M. Sarkar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Optically active (−)-ephedrine, (−)-norephedrine, and (−)-prolinol were immobilized onto cubic mesoporous MCM-48 silica. The immobilized amino alcohols served as a heterogeneous chiral catalyst for the asymmetric addition of diethylzinc to aldehydes and transfer hydrogenation to ketones. The developed catalytic process yielded optically enriches secondary aromatic alcohols with 92–99% conversion and 70–82% enantioselectivity.