Table 3: Asymmetric transfer hydrogenation of ketones using immobilized ligands 2ba.


Entry KetonebTime (h) Conv. (%)ce.e. (%)d

1 Acp 3 96 (92)e77 (74)e
2 Pp 3 94 70
3 3-OMe-Acp 3 98 75
44-Cl-Acp 3 99 71
5f4-Cl-Acp 4 92 82

The reactions were carried out at room temperature in 2-propanol; ketone : Ru : ligand : KOH = 100 : 1 : 2 : 5. bAcp = acetophenone and Pp = propiophenone. cDetermined by GC analysis. dDetermined by HPLC analysis using Chiralcel OD-H column (3% of 2-propanol in hexane, 1 mL/min). eThe catalyst was reused two times. f[RuCl2(hexamethylbenzene)]2 was used instead of [RuCl2(-cymene)]2.