Cisplatin Loaded Hyaluronic Acid Modified TiO₂ Nanoparticles for Neoadjuvant Chemotherapy of Ovarian Cancer

Figure 3

In vitro cellular internalization evaluation of HA-TiO₂ nanoparticles. (a) Cellular uptake of free C6, C6-loaded TiO₂ nanoparticles, and C6-loaded HA-TiO₂ nanoparticles with and without pretreatment with free HA polymer, in A2780 cells as a function of the incubation time (2 and 4 hours at 37°C). (b) Quantitative flow cytometric analysis of the intracellular uptake of free C6, C6-loaded TiO₂ nanoparticles, and C6-loaded HA-TiO₂ nanoparticles with and without HA pretreatment in A2780 cells for 2, 4, and 6 hours of incubation. Data were expressed as mean ± SD (). and . Scale bar: 20 μm.

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