Preparation, Characterization, and Dissolution Rate In Vitro Evaluation of Total Panax Notoginsenoside Nanoparticles, Typical Multicomponent Extracts from Traditional Chinese Medicine, Using Supercritical Antisolvent Process

Figure 2

Schematic diagram of the apparatus. (1) CO₂ cylinder; (2), (14), (15), (19), (21), (23), (24), (26), and (27) valves; (3) check valve; (4) CO₂ cooler; (5) liquid solution supply; (6) liquid pump; (7) and (9) flow meter; (8) CO₂ pump; (10), (13), and (20) heat exchangers; (11), (12), and (25) filters; (16) nozzle; (17) stainless steel frit vessel of 200 nm; (18) precipitation chamber; (22) gas-liquid separation chamber.