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Journal of Nanomaterials
Volume 2015, Article ID 481854, 7 pages
http://dx.doi.org/10.1155/2015/481854
Research Article

A Potential Solution to Minimally Invasive Device for Oral Surgery: Evaluation of Surgical Outcomes in Rat

1Graduate Institute of Biomedical Materials and Tissue Engineering, Taipei Medical University, Taipei 110, Taiwan
2Research Center for Biomedical Devices and Prototyping Production, Taipei Medical University, Taipei 110, Taiwan
3Research Center for Biomedical Implants and Microsurgery Devices, Taipei Medical University, Taipei 110, Taiwan
4Department of Dentistry, Taipei Medical University-Shuang Ho Hospital, Taipei 235, Taiwan
5School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan
6Division of Periodontics, Department of Dentistry, Cathay General Hospital, Daan District, Taipei 106, Taiwan
7School of Dental Technology, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan

Received 21 December 2014; Accepted 10 March 2015

Academic Editor: Abdelwahab Omri

Copyright © 2015 Keng-Liang Ou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The objective of the present research was to investigate the thermal injury in the brain after minimally invasive electrosurgery using instruments with copper-doped diamond-like carbon (DLC-Cu) surface coating. The surface morphologies of DLC-Cu thin films were characterized using scanning electron microscopy and atomic force microscopy. Three-dimensional brain models were reconstructed using magnetic resonance imaging to simulate the electrosurgical operation. In adult rats, a monopolar electrosurgical instrument coated with the DLC-Cu thin film was used to generate lesions in the brain. Animals were sacrificed for evaluations on postoperative days 0, 2, 7, and 28. Data indicated that the temperature decreased significantly when minimally invasive electrosurgical instruments with nanostructure DLC-Cu thin films were used and continued to decrease with increasing film thickness. On the other hand, the DLC-Cu-treated device created a relatively small thermal injury area and lateral thermal effect in the brain tissues. These results indicated that the DLC-Cu thin film minimized excessive thermal injury and uniformly distributed the temperature in the brain. Taken together, our study results suggest that the DLC-Cu film on copper electrode substrates is an effective means for improving the performance of electrosurgical instruments.