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Journal of Nanomaterials
Volume 2015 (2015), Article ID 530631, 8 pages
http://dx.doi.org/10.1155/2015/530631
Research Article

Sythesis, Modification, and Biosensing Characteristics of Au2S/AuAgS-Coated Gold Nanorods

1Institute of Photonics, Faculty of Science, Ningbo University, Ningbo, Zhejiang 315211, China
2School of Materials Science and Chemical Engineering, Ningbo University, Ningbo, Zhejiang 315211, China
3Fujian Provincial Key Laboratory for Photonics Technology, Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education, Fujian Normal University, Fuzhou 350007, China
4School of Information Science and Engineering, Ningbo University, Ningbo, Zhejiang 315211, China

Received 2 October 2014; Revised 6 January 2015; Accepted 20 January 2015

Academic Editor: Amir Kajbafvala

Copyright © 2015 Yanting Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The Au2S/AuAgS-coated gold nanorods (Au2S/AuAgS/GNRs) are prepared by a facile synthesis method and functionally modified for their biosensing application. In the preparation process, the longitudinal plasmon resonance (LPR) bands of Au2S/AuAgS/GNRs can be changed by controlling the thickness of the chalcogenide layer coated on GNRs. Especially, the LPR band located at 800 nm is obtained for biosensing application in the near-infrared region. Furthermore, mercaptoundecanoic acid (MUA) and poly(styrenesulfonate) (PSS) are, respectively, used to modify Au2S/AuAgS/GNRs to acquire the functional nanoprobes; that is, MUA-modified and PSS-modified Au2S/AuAgS/GNRs and their different chemical reaction mechanisms are studied by the absorption spectrum and ξ-potential measurement. Then, the functional nanoprobes are incubated with anti-prostate-specific antigen (PSA) antibody to detect PSA. The experimental results demonstrate that the functional nanoprobes are sensitive to the target binding of PSA. Therefore, Au2S/AuAgS/GNRs are suitable to form the bioprobes for detection of PSA in early-phase prostate cancer.