Preparation and In Vitro Evaluation of a Multifunctional Iron Silicate@Liposome Nanohybrid for pH-Sensitive Doxorubicin Delivery and Photoacoustic Imaging

Figure 6

(a) The enhanced DOX internalization by ILH: confocal laser scanning microscopic images of QSG-7703 cells incubated with DOX-loaded ILH and free DOX for 4 h and 8 h. (b) The decreased DAPI staining efficacy indicates the enhanced DOX intracellular trafficking and nucleus localization. (c) QSG-7703 cells (optical microscopy merged with confocal imaging) showed vacuolar degeneration when treated with DOX-ILH after 4 h, indicating an accelerated apoptosis. All the scale bars are 20 μm.

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