Optimization and Characterization of Artesunate-Loaded Chitosan-Decorated Poly(D,L-lactide-co-glycolide) Acid Nanoparticles

Table 1

Formulations of ART-loaded PLGA-CS NPs and their physicochemical characteristics.

Number	CS/PLGA ratio (w/w)	pH (CS solution)	Temp. (°C)	Size (nm)	PDI	Zeta potential (mV)
1	1.00	3.0	10	252.0	0.287	56.9
2	0.20	5.0	10	289.8	0.284	33.0
3	1.00	5.0	10	278.5	0.22	33.9
4	0.20	3.0	40	198.5	0.233	45.3
5	1.00	3.0	40	272.2	0.299	64.9
6	0.20	5.0	40	321.3	0.263	39.2
7	1.00	5.0	40	317.4	0.263	38.6
8	0.20	3.0	20	190.5	0.205	34.9
9	0.20	3.0	30	189.5	0.228	28.3
10	0.20	3.7	10	187.8	0.192	23.1
11	0.20	4.3	10	246.8	0.231	31.4
12	0.47	3.0	10	200.0	0.265	40.8
13	1.00	4.0	25	237.2	0.264	30.9
14	0.60	5.0	25	263.5	0.235	36.4
15	0.60	4.0	40	253.6	0.247	38.8
16	0.60	4.0	25	213.0	0.227	35.3
17	0.60	4.0	25	212.1	0.219	31.5
18	0.60	4.0	25	205.7	0.211	32.1