Research Article
Optimization and Characterization of Artesunate-Loaded Chitosan-Decorated Poly(D,L-lactide-co-glycolide) Acid Nanoparticles
Table 3
The optimal formulation of ART/PLGA-CS NPs.
| | Optimized independent variables | Predicted responses | Observed responses | | CS/PLGA ratio | pH of CS solution | Temp. (°C) | Size (nm) | Zeta potential (mV) | Size (nm) | Bias (%) | Zeta potential (mV) | Bias (%) |
| | 0.40 | 3.2 | 21.5 | 188.9 | 35.0 | 193.1 ± 1.012 | 2.22 | 36.2 ± 1.04 | 3.43 |
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Bias (%) = ((observed response − predicted response)/predicted response) × 100.
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