Development of Polymeric Nanoparticles of Garcinia mangostana Xanthones in Eudragit RL100/RS100 for Anti-Colon Cancer Drug Delivery

Table 5

Effect of surfactants on entrapment efficiency and particle size. The NPs were prepared at 20% drug loading with various surfactants, and the entrapment efficiency and particle size were measured by UV spectrophotometry and photon correlation spectroscopy, respectively. The results are presented as average ± SD ().

Formulation	Surfactant	Surfactant conc. % (wt/v)	Entrapment efficiency (%)	Particle size (nm)	Polydispersity index
F4-A	Tween 80	0.10	100.0 ± 0.3	39.0 ± 0.1	0.24 ± 0.01
F4-B	Tween 80	0.05	100.0 ± 0.3	48.0 ± 0.2	0.20 ± 0.01
F4-C	Tween 20	0.10	100.0 ± 0.5	44.0 ± 0.1	0.22 ± 0.01
F4-D	Tween 20	0.05	100.0 ± 0.7	39.0 ± 0.1	0.20 ± 0.01
F4-E	PVA	0.10	100.0 ± 0.4	55.0 ± 0.2	0.21 ± 0.01
F4-F	PVA	0.05	100.0 ± 0.3	47.0 ± 0.1	0.21 ± 0.01
F4-G	None	0.00	100.0 ± 0.1	46.0 ± 0.3	0.19 ± 0.01