Research Article

Development of Polymeric Nanoparticles of Garcinia mangostana Xanthones in Eudragit RL100/RS100 for Anti-Colon Cancer Drug Delivery

Table 6

Cake appearance of the freeze-dried NPs. The bulk NPs solutions were freeze-dried with various cryoprotectants at 0.25% (wt/v). The freeze-dried cakes were then identified as the following: intact with the same volume (IS), collapsed (C), and partially collapsed (PC).

CryoprotectantsFormulations
Cake appearance
Tween 80Tween 20PVANone
0.1%0.05%0.1%0.05%0.1%0.05%

SucroseISPCISISISISIS
GlucosePCPCISPCISISIS
MannitolPCISISISISISIS
GlycinePCISPCISISISIS
GlycerolCCCCPCPCPC
Dextran 40000ISISISISISISIS
NonePCPCPCISISISPC