Review Article

Recent Research Trends and Future Prospects in Nanozymes

Table 1

Various application studies based on nanozymes.

Application fieldNanozymesActivityDetection methodDetailsRef.

BiosensorMNPsPeroxidaseColorimetricH2O2 biosensor[9]
Au NPsGlucose oxidaseColorimetricNucleic acid detection[15]
Carboxyl-modified graphene oxidePeroxidaseColorimetricH2O2 and glucose biosensor[23]
MNPsPeroxidaseColorimetricH2O2 and glucose biosensor[44]
MNPsPeroxidaseColorimetricH2O2 biosensor[45]
MNPsPeroxidaseColorimetricH2O2 biosensor[46]
Au NPsPeroxidase ColorimetricH2O2 and glucose biosensor[47]
MNPsPeroxidaseElectrochemicalGlucose biosensor[48]
MNPs (with oxidase in mesoporous carbon)PeroxidaseElectrochemicalGlucose biosensor[49]
MNPs (with oxidase in mesoporous silica)PeroxidaseColorimetricGlucose and cholesterol biosensor[50]
MNPs (with oxidase in mesoporous silica)PeroxidaseColorimetricGalactose biosensor[51]
MNPs (with oxidase in mesoporous silica)PeroxidaseColorimetricAlcohol biosensor[52]
MNPsPeroxidaseColorimetricNucleic acid detection (Chlamydia trachomatis)[53]
CeO2 NPsOxidaseColorimetricNucleic acid detection (Chlamydia trachomatis)[56]
Chitosan-modified MNPs with thrombin aptamersPeroxidaseColorimetricThrombin detection[57]

ImmunoassayMNPsPeroxidaseColorimetricCardiac troponin I (TnI) detection[9]
MNPs-Pt NPs in mesoporous carbonPeroxidaseColorimetricRotavirus and HER2 detection[33]
Graphene oxidePeroxidaseColorimetricProstate specific antigen (PSA) detection[41]
Chitosan-modified MNPsPeroxidaseColorimetricMouse IgG and carcinoembryonic antigen detection[63]
Prussian blue modified γ-Fe2O3 NPsPeroxidaseColorimetricIgG detection[64]
FerritinsPeroxidaseFluorometricAvidin and human ceruloplasmin detection[65]
MNPsPeroxidaseColorimetricRotavirus and HER2 detection[66]
MNPs-Pt NPs on graphene oxidePeroxidaseColorimetric, fluorometricHER2 detection and imaging [35]

Cancer diagnostics (without immune reaction) and therapyPoly(acrylic acid)-coated CeO2 NPsOxidaseColorimetricLung cancer cell detection[13]
Poly(acrylic acid)-coated CeO2 NPsOxidaseColorimetricLung and breast cancer cell detection[69]
Magnetoferritin NPsPeroxidaseColorimetric, fluorometricCancer cell imaging[70]
CeO2 NPsSuperoxide dismutasePrevention of retinal degeneration[74]
CeO2 NPsSuperoxide dismutaseAnti-inflammation[75]
Superparamagnetic iron oxide NPsPeroxidasePromotion of stem cell growth[76]

Environmental engineeringMNPs (with oxidase in mesoporous carbon)PeroxidaseElectrochemicalPhenol, cresol, and cathechol detection[49]
MNPsPeroxidaseColorimetric Melamine detection[77]
MNPsPeroxidaseRemoval of phenol[78]
MNPsPeroxidaseRemoval of methylene blue[79]
MNPsPeroxidaseBiofilm degradation[80]