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Journal of Nanomaterials
Volume 2015, Article ID 761517, 10 pages
Research Article

Biocompatibility and Bioimaging Application of Carbon Nanoparticles Synthesized by Phosphorus Pentoxide Combustion Method

1National Biophotonics and Imaging Platform, School of Physical Sciences, Dublin City University, Glasnevin, Dublin 9, Ireland
2National Biophotonics and Imaging Platform, School of Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland
3Biomedical Diagnostics Institute, Dublin City University, Glasnevin, Dublin 9, Ireland
4School of Electronic Engineering, Dublin City University, Dublin 9, Ireland

Received 1 September 2015; Revised 20 October 2015; Accepted 22 October 2015

Academic Editor: Giovanni Bongiovanni

Copyright © 2015 Shibsekhar Roy et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Carbon nanoforms have emerged as a versatile bioimaging tool. In this work, we have synthesized four different carbon nanoparticles of different dimensions (10–100 nm) and variable fluorescence quantum efficiency (0.007 to 0.37) from four different carbon sources by phosphorus pentoxide-mediated combustion. The fluorescence quantum efficiency of the resulting self-passivated nanoparticles has been empirically correlated to the molecular weight and viscosity of the respective carbon source used in the synthesis. The carbon nanoparticles have been found to be significantly biocompatible as observed in the MTS assay. We have applied these biocompatible luminescent carbon nanoparticles as high brightness fluorescent probes for staining human blood platelets with very high target specificity.