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Journal of Nanomaterials
Volume 2015, Article ID 767945, 6 pages
http://dx.doi.org/10.1155/2015/767945
Research Article

Preparation of Cefquinome Nanoparticles by Using the Supercritical Antisolvent Process

1School of Mechanical Engineering, Shandong University, Jinan 250061, China
2College of Chemistry and Pharmaceutical Science, Qingdao Agricultural University, Qingdao 266109, China
3Shanda-Lunan Research Institute of Supercritical Fluid Technology, Shandong University, Jinan 250061, China
4The College of Electromechanical Engineering, Qingdao University of Science and Technology, Qingdao 266061, China

Received 15 September 2015; Accepted 5 November 2015

Academic Editor: John Zhanhu Guo

Copyright © 2015 Xiao Kefeng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The supercritical antisolvent process was used successfully to prepare nanoparticles of cefquinome. These particles were observed by scanning electron microscope (SEM) and their average diameter was measured by laser particle size analyzer. In the experiments, dimethyl sulfoxide (DMSO) was selected as solvent to dissolve cefquinome sulfate. It was confirmed by orthogonal experiments that the concentration of solution was the primary factor in this process followed by feeding speed of solution, precipitation pressure, and precipitation temperature. Moreover, the optimal conditions of preparing nanoparticles of cefquinome by supercritical antisolvent process were that solution concentration was 100 mg/mL, solution flow speed was 1.5 mL/min, operating pressure was 13 Mpa, and operating temperature was 33°C. Confirmatory experiment was conducted under this condition. It was found that the appearance of particles was flakes and the average diameter of particles was 0.71 microns. Finally, influence law of individual factor on particle size was investigated by univariate analysis.