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Journal of Nanomaterials
Volume 2015, Article ID 784574, 8 pages
Research Article

Antibacterial Membrane with a Bone-Like Structure for Guided Bone Regeneration

1College & Hospital of Stomatology, Anhui Medical University, Key Laboratory of Oral Diseases Research of Anhui Province, No. 69, Meishan Road, Hefei 230000, China
2Faculty of Dentistry, The University of Hong Kong, Pokfulam 999077, Hong Kong
3Department of Stomatology, The Second Affiliated Hospital of Anhui Medical University, Hefei 230000, China
4Department of Stomatology, The Hospital of Anhui Province, Hefei 230000, China

Received 6 June 2015; Revised 2 September 2015; Accepted 3 September 2015

Academic Editor: Victor M. Castaño

Copyright © 2015 YuYuan Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


An antibacterial membrane with a bone-like structure was developed for guided bone regeneration (GBR) by mineralising acellular bovine pericardium (ABP) and loading it with the antibiotic minocycline. The bovine pericardium (BP) membrane was processed using physical and chemical methods to remove the cellular components and obtain ABP membranes. Then, the ABP membranes were biomimetically mineralised using a calcium phosphate-loaded agarose hydrogel system aided by electrophoresis. Minocycline was adsorbed to the mineralised ABP membrane, and the release profile in vitro was studied. The membranes were characterised through scanning electron microscopy, diffuse reflectance-Fourier transform infrared spectroscopy, and X-ray diffraction. Results showed that the ABP membrane had an asymmetric structure with a layer of densely arranged and irregularly aligned collagen fibrils. Collagen fibrils were calcified with the formation of intrafibrillar and interfibrillar hydroxyapatites similar to the bone structure. Minocycline was incorporated into the mineralised collagen membrane and could be released in vitro. This process endowed the membrane with an antibacterial property. This novel composite membrane offers promising applications in bioactive GBR.