Controlling Surface-Induced Nanocomposites by Lipoplexes for Enhanced Gene Transfer

Figure 4

(a) Morphology and (b) the relative metabolic activities of B35 cells cultured on DNA- or lipoplex-nanocomposites formed from the indicated mineralizing formulation. The cells on tissue culture-treated surface (TC surface) were used as the control. The scale bar is 50 μm. The DNA : DOTAP ratio was 1 : 12 (w/w). The metabolic activity of cells on surfaces with DNA- or lipoplex-nanocomposites was considered statistically significantly different from that of cells on TC surfaces at .

(a)

(b)