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Journal of Nanomaterials
Volume 2015, Article ID 857154, 9 pages
Research Article

Core-Shell Structure of Gold Nanoparticles with Inositol Hexaphosphate Nanohybrids for Label-Free and Rapid Detection by SERS Nanotechnology

1Department of Materials Science and Engineering, National Taiwan University of Science and Technology, Taipei 106, Taiwan
2Department of Materials Engineering, Ming Chi University of Technology, New Taipei City 24301, Taiwan
3Center for Condensed Matter Sciences, National Taiwan University, Taipei 10617, Taiwan
4Institute of Atomic and Molecular Sciences, Academia Sinica, Taipei 10617, Taiwan
5Department of Physics, National Taiwan University, Taipei 10617, Taiwan

Received 5 February 2015; Accepted 16 March 2015

Academic Editor: Ping Yang

Copyright © 2015 Andreas H. H. Mevold et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Gold nanoparticles bound with inositol hexaphosphate (IP6) (AuNPs/IP6) were prepared by in situ reduction of various concentrations of IP6 (0~320 µM) through modified Frens method for surface-enhanced Raman scattering (SERS) detection. The resultant AuNPs/IP6 were subject to characterization including UV/Vis spectroscopy, transmission electron microscopy (TEM), dynamic light scattering (DLS), zeta potential, and X-ray photoelectron spectroscopy (XPS). The results showed that AuNPs with 65 µM of IP6 would result in a core AuNPs-shell (IP6 layer) structure, which exhibited the strongest SERS signal, due to the “hot spot effect” generated from the 1-2 nm interparticle gaps of AuNPs/IP6 nanohybrids (ionic interaction of IP6 and Au+). Furthermore, the reaction kinetics of Au and IP6 were also investigated in this work. Higher concentration of IP6 (190 and 260 µM) will make AuNPs become irregularly shaped, because IP6 is a basic salt and served as a pH mediator. The morphology and distribution of AuNPs were greatly improved by addition of 65 µM of IP6. This novel AuNPs/IP6 nanohybrid showed great stability and Raman enhancement. It is promising in the application of rapid and label-free biological detection of bacteria or tumor cells.