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Journal of Nanomaterials
Volume 2015, Article ID 908585, 10 pages
Research Article

Interfacial Interactions and Nanostructure Changes in DPPG/HD Monolayer at the Air/Water Interface

1College of Physics and Information Technology, Shaanxi Normal University, Chang-an Street No. 199, Xi’an 710062, China
2College of Science, Xi’an University of Science and Technology, Yanta Road No. 58, Xi’an 710054, China

Received 8 September 2015; Accepted 7 October 2015

Academic Editor: Jun Chen

Copyright © 2015 Huaze Zhu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Lung surfactant (LS) plays a crucial role in regulating surface tension during normal respiration cycles by decreasing the work associated with lung expansion and therefore decreases the metabolic energy consumed. Monolayer surfactant films composed of a mixture of phospholipids and spreading additives are of optional utility for applications in lung surfactant-based therapies. A simple, minimal model of such a lung surfactant system, composed of 1,2-dipalmitoyl-sn-glycero-3-[phosphor-rac-(1-gylcerol)] (DPPG) and hexadecanol (HD), was prepared, and the surface pressure-area (π-A) isotherms and nanostructure characteristics of the binary mixture were investigated at the air/water interface using a combination of Langmuir-Blodgett (LB) and atomic force microscopy (AFM) techniques. Based on the regular solution theory, the miscibility and stability of the two components in the monolayer were analyzed in terms of compression modulus () , excess Gibbs free energy () , activity coefficients (γ), and interaction parameter (ξ). The results of this paper provide valuable insight into basic thermodynamics and nanostructure of mixed DPPG/HD monolayers; it is helpful to understand the thermodynamic behavior of HD as spreading additive in LS monolayer with a view toward characterizing potential improvements to LS performance brought about by addition of HD to lung phospholipids.