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Journal of Nanomaterials
Volume 2015 (2015), Article ID 935439, 9 pages
http://dx.doi.org/10.1155/2015/935439
Research Article

Elaboration of Nanoparticles Containing Indomethacin: Argan Oil for Transdermal Local and Cosmetic Application

1University of Lyon 1, Villeurbanne, CNRS, UMR 5007, LAGEP-CPE, 43 boulevard 11 Novembre 1918, 69622 Villeurbanne, France
2Ecole Polytechnique de l’Université Internationale d’Agadir, Unité RDI en Génie Industriel et Génie des Procédés, Technopole d’Agadir, BP 8143, Agadir, Morocco

Received 13 November 2014; Revised 18 February 2015; Accepted 18 February 2015

Academic Editor: Zhongkui Hong

Copyright © 2015 Waisudin Badri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The objective of this work is the preparation of nanocapsules which are intended for the treatment of rheumatoid arthritis (RA). We use Argan oil as vehicle of hydrophobic drugs such as indomethacin. Nanoprecipitation technique was used like a method for preparation of nanocapsules, where polycaprolactone, acetone, and Argan oil are used as polymer, solvent, and carrier, respectively. Primarily, investigation of Argan oil amount addition was performed; then systematic study to optimize the formulation was done. Nanocapsules containing indomethacin (loaded nanocapsules) and others without indomethacin (blank nanocapsules) were characterized by studying particles size, zeta potential, and encapsulation efficiency. It is shown that particle size ranged between 290 nm and 350 nm. The zeta potential values were negative (from −40 up to −50 mV) while encapsulation efficiency ranged between 65 and 75%.