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Journal of Nanomaterials
Volume 2016, Article ID 1087250, 15 pages
http://dx.doi.org/10.1155/2016/1087250
Review Article

Design of Nanoparticle-Based Carriers for Targeted Drug Delivery

1Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
2Department of Chemical Physics, University of Science and Technology of China, Hefei, Anhui 230026, China

Received 8 December 2015; Revised 29 March 2016; Accepted 3 April 2016

Academic Editor: Martin Kröger

Copyright © 2016 Xiaojiao Yu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Nanoparticles have shown promise as both drug delivery vehicles and direct antitumor systems, but they must be properly designed in order to maximize efficacy. Computational modeling is often used both to design new nanoparticles and to better understand existing ones. Modeled processes include the release of drugs at the tumor site and the physical interaction between the nanoparticle and cancer cells. In this paper, we provide an overview of three different targeted drug delivery methods (passive targeting, active targeting, and physical targeting) and compare methods of action, advantages, limitations, and the current stages of research. For the most commonly used nanoparticle carriers, fabrication methods are also reviewed. This is followed by a review of computational simulations and models on nanoparticle-based drug delivery.