Design of Nanoparticle-Based Carriers for Targeted Drug Delivery

<div>Schematic representation of the disulfide cross-linked micelles formed by oxidization of self-assembled thiolated telodendrimer <svg height="12.4033pt" id="M1" style="vertical-align:-0.2456007pt" version="1.1" viewbox="-0.0498162 -12.1577 33.8459 12.4033" width="33.8459pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M46 650V622C120 617 128 613 128 525V125C128 42 120 34 40 28V0H311V28C221 34 212 39 212 124V281L286 262C297 261 316 261 331 263C429 275 526 338 526 468C526 533 501 579 462 609C422 638 364 650 293 650H46ZM212 559C212 588 215 600 223 606C230 613 251 618 279 618C361 618 430 572 430 464C430 337 350 302 285 302C252 302 225 309 212 314V559Z" id="g121-78"></path><glyph.data ascent="989" descent="-360" horiz-adv-x="563" vert-adv-y="563"></glyph.data></g><g transform="matrix(.013,0,0,-0.013,7.254,0)"><path d="M517 162C503 123 484 88 467 68C445 42 417 34 341 34C291 34 256 34 237 47C219 59 213 81 213 128V317H308C395 317 402 311 415 240H444V431H415C403 364 398 356 307 356H213V584C213 613 215 616 246 616H322C394 616 421 609 435 587C448 566 458 544 467 502L496 506C493 557 488 625 488 650H42V622C120 616 128 612 128 523V125C128 43 120 35 29 28V0H511C520 31 540 125 546 158L517 162Z" id="g121-67"></path><glyph.data ascent="989" descent="-360" horiz-adv-x="568" vert-adv-y="568"></glyph.data></g><g transform="matrix(.013,0,0,-0.013,14.638,0)"><path d="M692 302H438V274C537 267 543 260 543 188V103C543 61 531 48 511 37C489 26 458 20 424 20C231 20 146 188 146 333C146 517 258 630 411 630C507 630 582 597 606 474L634 480C627 546 622 601 619 636C586 643 510 665 426 665C230 665 44 552 44 321C44 122 191 -15 411 -15C491 -15 573 7 635 21C629 49 628 81 628 116V202C628 261 632 266 692 274V302Z" id="g121-69"></path><glyph.data ascent="989" descent="-360" horiz-adv-x="715" vert-adv-y="715"></glyph.data></g><g transform="matrix(.0091,0,0,-0.0091,23.933,-5.741)"><path d="M158 548H390L417 615L410 623H122L83 318C105 326 143 337 185 337C296 337 350 275 350 188C350 116 308 42 225 42C164 42 122 74 100 93C90 101 82 99 72 92C60 82 51 68 50 59C48 46 52 38 66 24C82 9 125 -12 172 -12C225 -11 292 15 346 59C408 108 437 166 437 226C437 309 371 397 242 397C214 397 170 382 133 369L158 548Z" id="g50-54"></path><glyph.data ascent="3443" descent="-2856" horiz-adv-x="487" vert-adv-y="487"></glyph.data></g><g transform="matrix(.0091,0,0,-0.0091,28.365,-5.741)"><path d="M523 0V30C483 33 455 48 422 83C390 115 285 234 266 263C309 314 327 333 351 357C388 392 414 404 483 415V444L273 435V405C320 400 321 392 302 364C285 339 256 300 233 277C218 262 201 250 170 243V710C130 697 73 680 22 675V647C85 642 89 637 89 570V107C89 44 83 35 14 30V0H244V30C179 35 170 41 170 107V214C176 216 181 217 186 217C194 217 203 212 216 196C273 129 333 54 384 -1L523 0Z" id="g58-105"></path><glyph.data ascent="1007" descent="-369" horiz-adv-x="507" vert-adv-y="507"></glyph.data></g></svg>-Cys<sub>4</sub>-L<sub>8</sub>-CA<sub>8</sub> [<a href="/journals/jnm/2016/1087250/#B27">15</a>]. Schematic representation of the telodendrimer pair [<svg height="12.4033pt" id="M2" style="vertical-align:-0.2456007pt" version="1.1" viewbox="-0.0498162 -12.1577 33.8459 12.4033" width="33.8459pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M46 650V622C120 617 128 613 128 525V125C128 42 120 34 40 28V0H311V28C221 34 212 39 212 124V281L286 262C297 261 316 261 331 263C429 275 526 338 526 468C526 533 501 579 462 609C422 638 364 650 293 650H46ZM212 559C212 588 215 600 223 606C230 613 251 618 279 618C361 618 430 572 430 464C430 337 350 302 285 302C252 302 225 309 212 314V559Z" id="g121-78"></path><glyph.data ascent="989" descent="-360" horiz-adv-x="563" vert-adv-y="563"></glyph.data></g><g transform="matrix(.013,0,0,-0.013,7.254,0)"><path d="M517 162C503 123 484 88 467 68C445 42 417 34 341 34C291 34 256 34 237 47C219 59 213 81 213 128V317H308C395 317 402 311 415 240H444V431H415C403 364 398 356 307 356H213V584C213 613 215 616 246 616H322C394 616 421 609 435 587C448 566 458 544 467 502L496 506C493 557 488 625 488 650H42V622C120 616 128 612 128 523V125C128 43 120 35 29 28V0H511C520 31 540 125 546 158L517 162Z" id="g121-67"></path><glyph.data ascent="989" descent="-360" horiz-adv-x="568" vert-adv-y="568"></glyph.data></g><g transform="matrix(.013,0,0,-0.013,14.638,0)"><path d="M692 302H438V274C537 267 543 260 543 188V103C543 61 531 48 511 37C489 26 458 20 424 20C231 20 146 188 146 333C146 517 258 630 411 630C507 630 582 597 606 474L634 480C627 546 622 601 619 636C586 643 510 665 426 665C230 665 44 552 44 321C44 122 191 -15 411 -15C491 -15 573 7 635 21C629 49 628 81 628 116V202C628 261 632 266 692 274V302Z" id="g121-69"></path><glyph.data ascent="989" descent="-360" horiz-adv-x="715" vert-adv-y="715"></glyph.data></g><g transform="matrix(.0091,0,0,-0.0091,23.933,-5.741)"><path d="M158 548H390L417 615L410 623H122L83 318C105 326 143 337 185 337C296 337 350 275 350 188C350 116 308 42 225 42C164 42 122 74 100 93C90 101 82 99 72 92C60 82 51 68 50 59C48 46 52 38 66 24C82 9 125 -12 172 -12C225 -11 292 15 346 59C408 108 437 166 437 226C437 309 371 397 242 397C214 397 170 382 133 369L158 548Z" id="g50-54"></path><glyph.data ascent="3443" descent="-2856" horiz-adv-x="487" vert-adv-y="487"></glyph.data></g><g transform="matrix(.0091,0,0,-0.0091,28.365,-5.741)"><path d="M523 0V30C483 33 455 48 422 83C390 115 285 234 266 263C309 314 327 333 351 357C388 392 414 404 483 415V444L273 435V405C320 400 321 392 302 364C285 339 256 300 233 277C218 262 201 250 170 243V710C130 697 73 680 22 675V647C85 642 89 637 89 570V107C89 44 83 35 14 30V0H244V30C179 35 170 41 170 107V214C176 216 181 217 186 217C194 217 203 212 216 196C273 129 333 54 384 -1L523 0Z" id="g58-105"></path><glyph.data ascent="1007" descent="-369" horiz-adv-x="507" vert-adv-y="507"></glyph.data></g></svg>-(boronic acid or catechol)<sub>4</sub>-CA<sub>8</sub>] and the resulting boronate cross-linked micelles (BCM) triggered by mannitol and/or acidic pH values [<a href="/journals/jnm/2016/1087250/#B28">16</a>].</div>

Journal of Nanomaterials

Design of Nanoparticle-Based Carriers for Targeted Drug Delivery

Figure 4