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Journal of Nanomaterials
Volume 2016 (2016), Article ID 1087250, 15 pages
http://dx.doi.org/10.1155/2016/1087250
Review Article

Design of Nanoparticle-Based Carriers for Targeted Drug Delivery

Xiaojiao Yu,1 Ian Trase,1 Muqing Ren,2 Kayla Duval,1 Xing Guo,1 and Zi Chen1

1Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
2Department of Chemical Physics, University of Science and Technology of China, Hefei, Anhui 230026, China

Received 8 December 2015; Revised 29 March 2016; Accepted 3 April 2016

Academic Editor: Martin Kröger

Copyright © 2016 Xiaojiao Yu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. N. A. Ochekpe, P. O. Olorunfemi, and N. C. Ngwuluka, “Nanotechnology and drug delivery—part 1: background and applications,” Tropical Journal of Pharmaceutical Research, vol. 8, no. 3, pp. 265–274, 2009. View at Google Scholar · View at Scopus
  2. G. Poste and R. Kirsh, “Site-specific (targeted) drug delivery in cancer therapy,” Bio/Technology, vol. 1, no. 10, pp. 869–878, 1983. View at Publisher · View at Google Scholar · View at Scopus
  3. G. M. Whitesides, J. K. Kriebel, and B. T. Mayers, “Self-assembly and nanostructured materials,” in Nanoscale Assembly: Chemical Techniques, Nanostructure Science and Technology, pp. 217–239, Springer, Berlin, Germany, 2005. View at Publisher · View at Google Scholar
  4. S. Svenson and D. A. Tomalia, “Dendrimers in biomedical applications—reflections on the field,” Advanced Drug Delivery Reviews, vol. 57, no. 15, pp. 2106–2129, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. E. Igarashi, “Factors affecting toxicity and efficacy of polymeric nanomedicines,” Toxicology and Applied Pharmacology, vol. 229, no. 1, pp. 121–134, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. A. Mahmud, X.-B. Xiong, H. M. Aliabadi, and A. Lavasanifar, “Polymeric micelles for drug targeting,” Journal of Drug Targeting, vol. 15, no. 9, pp. 553–584, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. V. P. Torchilin, “Targeted polymeric micelles for delivery of poorly soluble drugs,” Cellular and Molecular Life Sciences, vol. 61, no. 19-20, pp. 2549–2559, 2004. View at Publisher · View at Google Scholar · View at Scopus
  8. H. Maeda, T. Sawa, and T. Konno, “Mechanism of tumor-targeted delivery of macromolecular drugs, including the EPR effect in solid tumor and clinical overview of the prototype polymeric drug SMANCS,” Journal of Controlled Release, vol. 74, no. 1–3, pp. 47–61, 2001. View at Publisher · View at Google Scholar · View at Scopus
  9. F. Yuan, M. Dellian, D. Fukumura et al., “Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size,” Cancer Research, vol. 55, no. 17, pp. 3752–3756, 1995. View at Google Scholar · View at Scopus
  10. N. Bertrand, J. Wu, X. Xu, N. Kamaly, and O. C. Farokhzad, “Cancer nanotechnology: the impact of passive and active targeting in the era of modern cancer biology,” Advanced Drug Delivery Reviews, vol. 66, pp. 2–25, 2014. View at Publisher · View at Google Scholar · View at Scopus
  11. E. Ruoslahti, “Specialization of tumour vasculature,” Nature Reviews Cancer, vol. 2, no. 2, pp. 83–90, 2002. View at Publisher · View at Google Scholar · View at Scopus
  12. N. Haddish-Berhane, J. L. Rickus, and K. Haghighi, “The role of multiscale computational approaches for rational design of conventional and nanoparticle oral drug delivery systems,” International Journal of Nanomedicine, vol. 2, no. 3, pp. 315–331, 2007. View at Google Scholar · View at Scopus
  13. L. Zhang, T. Su, B. He, and Z. Gu, “Self-assembly polyrotaxanes nanoparticles as carriers for anticancer drug methotrexate delivery,” Nano-Micro Letters, vol. 6, no. 2, pp. 108–115, 2014. View at Publisher · View at Google Scholar · View at Scopus
  14. Y. Wang, K. Wang, J. Zhao et al., “Multifunctional mesoporous silica-coated graphene nanosheet used for chemo-photothermal synergistic targeted therapy of glioma,” Journal of the American Chemical Society, vol. 135, no. 12, pp. 4799–4804, 2013. View at Publisher · View at Google Scholar · View at Scopus
  15. Y. Li, K. Xiao, J. Luo et al., “Well-defined, reversible disulfide cross-linked micelles for on-demand paclitaxel delivery,” Biomaterials, vol. 32, no. 27, pp. 6633–6645, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. Y. Li, W. Xiao, K. Xiao et al., “Well-defined, reversible boronate crosslinked nanocarriers for targeted drug delivery in response to acidic pH values and cis-diols,” Angewandte Chemie—International Edition, vol. 124, no. 12, pp. 2918–2923, 2012. View at Publisher · View at Google Scholar
  17. T. Aida, E. W. Meijer, and S. I. Stupp, “Functional supramolecular polymers,” Science, vol. 335, no. 6070, pp. 813–817, 2012. View at Publisher · View at Google Scholar · View at Scopus
  18. X. Xia, M. Yang, Y. Wang et al., “Quantifying the coverage density of poly(ethylene glycol) chains on the surface of gold nanostructures,” ACS Nano, vol. 6, no. 1, pp. 512–522, 2012. View at Publisher · View at Google Scholar · View at Scopus
  19. B. Tang, S. Xu, J. An, B. Zhao, W. Xu, and J. R. Lombardi, “Kinetic effects of halide ions on the morphological evolution of silver nanoplates,” Physical Chemistry Chemical Physics, vol. 11, no. 44, pp. 10286–10292, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. Y. Li, M. Kröger, and W. K. Liu, “Shape effect in cellular uptake of PEGylated nanoparticles: comparison between sphere, rod, cube and disk,” Nanoscale, vol. 7, no. 40, pp. 16631–16646, 2015. View at Publisher · View at Google Scholar · View at Scopus
  21. G. S. Kwon, M. Yokoyama, T. Okano, Y. Sakurai, and K. Kataoka, “Biodistribution of micelle-forming polymer-drug conjugates,” Pharmaceutical Research, vol. 10, no. 7, pp. 970–974, 1993. View at Publisher · View at Google Scholar · View at Scopus
  22. K. Na, T. B. Lee, K.-H. Park, E.-K. Shin, Y.-B. Lee, and H.-K. Choi, “Self-assembled nanoparticles of hydrophobically-modified polysaccharide bearing vitamin H as a targeted anti-cancer drug delivery system,” European Journal of Pharmaceutical Sciences, vol. 18, no. 2, pp. 165–173, 2003. View at Publisher · View at Google Scholar · View at Scopus
  23. Y. Bae, S. Fukushima, A. Harada, and K. Kataoka, “Design of environment-sensitive supramolecular assemblies for intracellular drug delivery: polymeric micelles that are responsive to intracellular pH change,” Angewandte Chemie—International Edition, vol. 42, no. 38, pp. 4640–4643, 2003. View at Publisher · View at Google Scholar · View at Scopus
  24. G. Li, S. Song, L. Guo, and S. Ma, “Self-assembly of thermo- and pH-responsive poly(acrylic acid)-b-poly(N-isopropylacrylamide) micelles for drug delivery,” Journal of Polymer Science, Part A: Polymer Chemistry, vol. 46, no. 15, pp. 5028–5035, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. A. Rahikkala, V. Aseyev, H. Tenhu, E. I. Kauppinen, and J. Raula, “Thermoresponsive nanoparticles of self-assembled block copolymers as potential carriers for drug delivery and diagnostics,” Biomacromolecules, vol. 16, no. 9, pp. 2750–2756, 2015. View at Publisher · View at Google Scholar · View at Scopus
  26. Y. Wang, S. Gao, W.-H. Ye, H. S. Yoon, and Y.-Y. Yang, “Co-delivery of drugs and DNA from cationic core-shell nanoparticles self-assembled from a biodegradable copolymer,” Nature Materials, vol. 5, no. 10, pp. 791–796, 2006. View at Publisher · View at Google Scholar · View at Scopus
  27. L. Zhang, J. M. Chan, F. X. Gu et al., “Self-assembled lipid-polymer hybrid nanoparticles: a robust drug delivery platform,” ACS Nano, vol. 2, no. 8, pp. 1696–1702, 2008. View at Publisher · View at Google Scholar · View at Scopus
  28. B. Karagoz, L. Esser, H. T. Duong, J. S. Basuki, C. Boyer, and T. P. Davis, “Polymerization-Induced Self-Assembly (PISA)—control over the morphology of nanoparticles for drug delivery applications,” Polymer Chemistry, vol. 5, no. 2, pp. 350–355, 2014. View at Publisher · View at Google Scholar · View at Scopus
  29. F. Huang, M. You, T. Chen, G. Zhu, H. Liang, and W. Tan, “Self-assembled hybrid nanoparticles for targeted co-delivery of two drugs into cancer cells,” Chemical Communications, vol. 50, no. 23, pp. 3103–3105, 2014. View at Publisher · View at Google Scholar · View at Scopus
  30. J. Li, X. Qu, G. F. Payne et al., “Biospecific self-assembly of a nanoparticle coating for targeted and stimuli-responsive drug delivery,” Advanced Functional Materials, vol. 25, no. 9, pp. 1404–1417, 2015. View at Publisher · View at Google Scholar · View at Scopus
  31. X.-X. Xia, M. Wang, Y. Lin, Q. Xu, and D. L. Kaplan, “Hydrophobic drug-triggered self-assembly of nanoparticles from silk-elastin-like protein polymers for drug delivery,” Biomacromolecules, vol. 15, no. 3, pp. 908–914, 2014. View at Publisher · View at Google Scholar · View at Scopus
  32. A. K. Patri, A. Myc, J. Beals, T. P. Thomas, N. H. Bander, and J. R. Baker Jr., “Synthesis and in vitro testing of J591 antibody-dendrimer conjugates for targeted prostate cancer therapy,” Bioconjugate Chemistry, vol. 15, no. 6, pp. 1174–1181, 2004. View at Publisher · View at Google Scholar · View at Scopus
  33. R. Liu, Y. Lai, B. He et al., “Supramolecular nanoparticles generated by the self-assembly of polyrotaxanes for antitumor drug delivery,” International Journal of Nanomedicine, vol. 7, pp. 5249–5258, 2012. View at Publisher · View at Google Scholar · View at Scopus
  34. A. Sahu, W. I. Choi, J. H. Lee, and G. Tae, “Graphene oxide mediated delivery of methylene blue for combined photodynamic and photothermal therapy,” Biomaterials, vol. 34, no. 26, pp. 6239–6248, 2013. View at Publisher · View at Google Scholar · View at Scopus
  35. A. C. Estrada, A. L. Daniel-da-Silva, and T. Trindade, “Photothermally enhanced drug release by κ-carrageenan hydrogels reinforced with multi-walled carbon nanotubes,” RSC Advances, vol. 3, no. 27, pp. 10828–10836, 2013. View at Publisher · View at Google Scholar
  36. H. Zhang, C. Chen, L. Hou et al., “Targeting and hyperthermia of doxorubicin by the delivery of single-walled carbon nanotubes to EC-109 cells,” Journal of Drug Targeting, vol. 21, no. 3, pp. 312–319, 2013. View at Publisher · View at Google Scholar · View at Scopus
  37. B. Thiesen and A. Jordan, “Clinical applications of magnetic nanoparticles for hyperthermia,” International Journal of Hyperthermia, vol. 24, no. 6, pp. 467–474, 2008. View at Publisher · View at Google Scholar · View at Scopus
  38. R. Mo, Q. Sun, N. Li, and C. Zhang, “Intracellular delivery and antitumor effects of pH-sensitive liposomes based on zwitterionic oligopeptide lipids,” Biomaterials, vol. 34, no. 11, pp. 2773–2786, 2013. View at Publisher · View at Google Scholar · View at Scopus
  39. N. Desai, “Challenges in development of nanoparticle-based therapeutics,” AAPS Journal, vol. 14, no. 2, pp. 282–295, 2012. View at Publisher · View at Google Scholar · View at Scopus
  40. A. G. Tzakos, E. Briasoulis, T. Thalhammer, W. Jäger, and V. Apostolopoulos, “Novel oncology therapeutics: targeted drug delivery for cancer,” Journal of Drug Delivery, vol. 2013, Article ID 918304, 5 pages, 2013. View at Publisher · View at Google Scholar
  41. G. D. Grossfeld, P. R. Carroll, N. Lindeman et al., “Thrombospondin-1 expression in patients with pathologic stage T3 prostate cancer undergoing radical prostatectomy: association with p53 alterations, tumor angiogenesis, and tumor progression,” Urology, vol. 59, no. 1, pp. 97–102, 2002. View at Publisher · View at Google Scholar · View at Scopus
  42. A. Jones and A. L. Harris, “New developments in angiogenesis: a major mechanism for tumor growth and target for therapy,” Cancer Journal from Scientific American, vol. 4, no. 4, pp. 209–217, 1998. View at Google Scholar · View at Scopus
  43. J. I. N. Zhang, C. Q. Lan, M. Post, B. Simard, Y. Deslandes, and T. H. Hsieh, “Design of nanoparticles as drug carriers for cancer therapy,” Cancer Genomics and Proteomics, vol. 3, no. 3-4, pp. 147–157, 2006. View at Google Scholar · View at Scopus
  44. G. Poste, “Experimental systems for analysis of the malignant phenotype,” Cancer and Metastasis Review, vol. 1, no. 2, pp. 141–199, 1982. View at Publisher · View at Google Scholar · View at Scopus
  45. G. Poste and I. J. Fidler, “The pathogenesis of cancer metastasis,” Nature, vol. 283, no. 5743, pp. 139–146, 1980. View at Publisher · View at Google Scholar · View at Scopus
  46. Y. Matsumura and H. Maeda, “A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent Smancs,” Cancer Research, vol. 46, no. 12, pp. 6387–6392, 1986. View at Google Scholar · View at Scopus
  47. L. Y. T. Chou, K. Ming, and W. C. W. Chan, “Strategies for the intracellular delivery of nanoparticles,” Chemical Society Reviews, vol. 40, no. 1, pp. 233–245, 2011. View at Publisher · View at Google Scholar · View at Scopus
  48. A. Albanese, P. S. Tang, and W. C. W. Chan, “The effect of nanoparticle size, shape, and surface chemistry on biological systems,” Annual Review of Biomedical Engineering, vol. 14, pp. 1–16, 2012. View at Publisher · View at Google Scholar · View at Scopus
  49. C. He, Y. Hu, L. Yin, C. Tang, and C. Yin, “Effects of particle size and surface charge on cellular uptake and biodistribution of polymeric nanoparticles,” Biomaterials, vol. 31, no. 13, pp. 3657–3666, 2010. View at Publisher · View at Google Scholar · View at Scopus
  50. F. Alexis, E. Pridgen, L. K. Molnar, and O. C. Farokhzad, “Factors affecting the clearance and biodistribution of polymeric nanoparticles,” Molecular Pharmaceutics, vol. 5, no. 4, pp. 505–515, 2008. View at Publisher · View at Google Scholar · View at Scopus
  51. Y. Li, M. Kröger, and W. K. Liu, “Endocytosis of PEGylated nanoparticles accompanied by structural and free energy changes of the grafted polyethylene glycol,” Biomaterials, vol. 35, no. 30, pp. 8467–8478, 2014. View at Publisher · View at Google Scholar · View at Scopus
  52. Y. H. Bae and K. Park, “Targeted drug delivery to tumors: myths, reality and possibility,” Journal of Controlled Release, vol. 153, no. 3, pp. 198–205, 2011. View at Publisher · View at Google Scholar · View at Scopus
  53. D. Oupicky, M. Ogris, K. A. Howard, P. R. Dash, K. Ulbrich, and L. W. Seymour, “Importance of lateral and steric stabilization of polyelectrolyte gene delivery vectors for extended systemic circulation,” Molecular Therapy, vol. 5, no. 4, pp. 463–472, 2002. View at Publisher · View at Google Scholar · View at Scopus
  54. X. Guo, C. Shi, G. Yang, J. Wang, Z. Cai, and S. Zhou, “Dual-responsive polymer micelles for target-cell-specific anticancer drug delivery,” Chemistry of Materials, vol. 26, no. 15, pp. 4405–4418, 2014. View at Publisher · View at Google Scholar · View at Scopus
  55. J. Kreuter, “Nanoparticles-a historical perspective,” International Journal of Pharmaceutics, vol. 331, no. 1, pp. 1–10, 2007. View at Publisher · View at Google Scholar · View at Scopus
  56. R. N. Saha, S. Vasanthakumar, G. Bende, and M. Snehalatha, “Nanoparticulate drug delivery systems for cancer chemotherapy,” Molecular Membrane Biology, vol. 27, no. 7, pp. 215–231, 2010. View at Publisher · View at Google Scholar
  57. S. Ganta, H. Devalapally, A. Shahiwala, and M. Amiji, “A review of stimuli-responsive nanocarriers for drug and gene delivery,” Journal of Controlled Release, vol. 126, no. 3, pp. 187–204, 2008. View at Publisher · View at Google Scholar · View at Scopus
  58. A. A. Kale and V. P. Torchilin, “Environment-responsive multifunctional liposomes,” Methods in Molecular Biology, vol. 605, pp. 213–242, 2010. View at Publisher · View at Google Scholar · View at Scopus
  59. K. T. Oh, H. Yin, E. S. Lee, and Y. H. Bae, “Polymeric nanovehicles for anticancer drugs with triggering release mechanisms,” Journal of Materials Chemistry, vol. 17, no. 38, pp. 3987–4001, 2007. View at Publisher · View at Google Scholar · View at Scopus
  60. M. Zorko and Ü. Langel, “Cell-penetrating peptides: mechanism and kinetics of cargo delivery,” Advanced Drug Delivery Reviews, vol. 57, no. 4, pp. 529–545, 2005. View at Publisher · View at Google Scholar · View at Scopus
  61. E. Ruoslahti, S. N. Bhatia, and M. J. Sailor, “Targeting of drugs and nanoparticles to tumors,” Journal of Cell Biology, vol. 188, no. 6, pp. 759–768, 2010. View at Publisher · View at Google Scholar · View at Scopus
  62. S. Christian, J. Pilch, M. E. Akerman, K. Porkka, P. Laakkonen, and E. Ruoslahti, “Nucleolin expressed at the cell surface is a marker of endothelial cells in angiogenic blood vessels,” The Journal of Cell Biology, vol. 163, no. 4, pp. 871–878, 2003. View at Publisher · View at Google Scholar · View at Scopus
  63. P. Oh, Y. Li, J. Yu et al., “Subtractive proteomic mapping of the endothelial surface in lung and solid tumours for tissue-specific therapy,” Nature, vol. 429, no. 6992, pp. 629–635, 2004. View at Publisher · View at Google Scholar · View at Scopus
  64. K. A. Kelly, N. Bardeesy, R. Anbazhagan et al., “Targeted nanoparticles for imaging incipient pancreatic ductal adenocarcinoma,” PLoS Medicine, vol. 5, no. 4, article e85, 2008. View at Publisher · View at Google Scholar · View at Scopus
  65. V. Fogal, L. Zhang, S. Krajewski, and E. Ruoslahti, “Mitochondrial/cell-surface protein p32/gC1qR as a molecular target in tumor cells and tumor stroma,” Cancer Research, vol. 68, no. 17, pp. 7210–7218, 2008. View at Publisher · View at Google Scholar · View at Scopus
  66. P. C. Brooks, R. A. F. Clark, and D. A. Cheresh, “Requirement of vascular integrin alpha v beta 3 for angiogenesis,” Science, vol. 264, no. 5158, pp. 569–571, 1994. View at Publisher · View at Google Scholar · View at Scopus
  67. A. Erdreich-Epstein, H. Shimada, S. Groshen et al., “Integrins α(v)β3 and α(v)β5 are expressed by endothelium of high—risk neuroblastoma and their inhibition is associated with increased endogenous ceramide,” Cancer Research, vol. 60, no. 3, pp. 712–721, 2000. View at Google Scholar · View at Scopus
  68. J. S. Desgrosellier and D. A. Cheresh, “Integrins in cancer: biological implications and therapeutic opportunities,” Nature Reviews Cancer, vol. 10, no. 1, pp. 9–22, 2010. View at Publisher · View at Google Scholar · View at Scopus
  69. F. Nilsson, H. Kosmehl, L. Zardi, and D. Neri, “Targeted delivery of tissue factor to the ED-B domain of fibronectin, a marker of angiogenesis, mediates the infarction of solid tumors in mice,” Cancer Research, vol. 61, no. 2, pp. 711–716, 2001. View at Google Scholar · View at Scopus
  70. E. B. Carson-Walter, D. N. Watkins, A. Nanda, B. Vogelstein, K. W. Kinzler, and B. St Croix, “Cell surface tumor endothelial markers are conserved in mice and humans,” Cancer Research, vol. 61, no. 18, pp. 6649–6655, 2001. View at Google Scholar
  71. A. A. Gabizon, “Pegylated liposomal doxorubicin: metamorphosis of an old drug into a new form of chemotherapy,” Cancer Investigation, vol. 19, no. 4, pp. 424–436, 2001. View at Publisher · View at Google Scholar · View at Scopus
  72. P. S. Low, W. A. Henne, and D. D. Doorneweerd, “Discovery and development of folic-acid-based receptor targeting for imaging and therapy of cancer and inflammatory diseases,” Accounts of Chemical Research, vol. 41, no. 1, pp. 120–129, 2008. View at Publisher · View at Google Scholar · View at Scopus
  73. Z. Cheng, A. Al Zaki, J. Z. Hui, V. R. Muzykantov, and A. Tsourkas, “Multifunctional nanoparticles: cost versus benefit of adding targeting and imaging capabilities,” Science, vol. 338, no. 6109, pp. 903–910, 2012. View at Publisher · View at Google Scholar · View at Scopus
  74. X. Huang, P. K. Jain, I. H. El-Sayed, and M. A. El-Sayed, “Plasmonic photothermal therapy (PPTT) using gold nanoparticles,” Lasers in Medical Science, vol. 23, no. 3, pp. 217–228, 2008. View at Publisher · View at Google Scholar · View at Scopus
  75. A. S. Sreedhar and P. Csermely, “Heat shock proteins in the regulation of apoptosis: new strategies in tumor therapy: a comprehensive review,” Pharmacology & Therapeutics, vol. 101, no. 3, pp. 227–257, 2004. View at Publisher · View at Google Scholar · View at Scopus
  76. D. R. Stacy, B. Lu, and D. E. Hallahan, “Radiation-guided drug delivery systems,” Expert Review of Anticancer Therapy, vol. 4, no. 2, 2014. View at Publisher · View at Google Scholar
  77. S. C. McBain, H. H. P. Yiu, and J. Dobson, “Magnetic nanoparticles for gene and drug delivery,” International Journal of Nanomedicine, vol. 3, no. 2, pp. 169–180, 2008. View at Google Scholar · View at Scopus
  78. N. Schleich, C. Po, D. Jacobs et al., “Comparison of active, passive and magnetic targeting to tumors of multifunctional paclitaxel/SPIO-loaded nanoparticles for tumor imaging and therapy,” Journal of Controlled Release, vol. 194, pp. 82–91, 2014. View at Publisher · View at Google Scholar · View at Scopus
  79. S. R. McDougall, A. R. A. Anderson, M. A. J. Chaplain, and J. A. Sherratt, “Mathematical modelling of flow through vascular networks: implications for tumour-induced angiogenesis and chemotherapy strategies,” Bulletin of Mathematical Biology, vol. 64, no. 4, pp. 673–702, 2002. View at Publisher · View at Google Scholar · View at Scopus
  80. J. Siepmann and N. A. Peppas, “Mathematical modeling of controlled drug delivery,” Advanced Drug Delivery Reviews, vol. 48, no. 2-3, pp. 137–138, 2001. View at Publisher · View at Google Scholar · View at Scopus
  81. G. Fullstone, J. Wood, M. Holcombe, and G. Battaglia, “Modelling the transport of nanoparticles under blood flow using an agent-based approach,” Scientific Reports, vol. 5, Article ID 10649, 2015. View at Google Scholar
  82. W. M. Saltzman and M. L. Radomsky, “Drugs released from polymers: diffusion and elimination in brain tissue,” Chemical Engineering Science, vol. 46, no. 10, pp. 2429–2444, 1991. View at Publisher · View at Google Scholar · View at Scopus
  83. R. Langer and N. Peppas, “Chemical and physical structure of polymers as carriers for controlled release of bioactive agents: a review,” Journal of Macromolecular Science, Part C, vol. 23, pp. 61–126, 2006. View at Google Scholar
  84. J. Siepmann and A. Göpferich, “Mathematical modeling of bioerodible, polymeric drug delivery systems,” Advanced Drug Delivery Reviews, vol. 48, no. 2-3, pp. 229–247, 2001. View at Publisher · View at Google Scholar · View at Scopus
  85. D. Neumann, C.-M. Lehr, H.-P. Lenhof, and O. Kohlbacher, “Computational modeling of the sugar-lectin interaction,” Advanced Drug Delivery Reviews, vol. 56, no. 4, pp. 437–457, 2004. View at Publisher · View at Google Scholar · View at Scopus
  86. P. Adhikari, A. M. Wen, R. H. French et al., “Electronic structure, dielectric response, and surface charge distribution of RGD (1FUV) peptide,” Scientific Reports, vol. 4, article 5605, 2014. View at Publisher · View at Google Scholar · View at Scopus
  87. S. M. Loverde, M. L. Klein, and D. E. Discher, “Nanoparticle shape improves delivery: rational coarse grain molecular dynamics (rCG-MD) of taxol in worm-like PEG-PCL micelles,” Advanced Materials, vol. 24, no. 28, pp. 3823–3830, 2012. View at Publisher · View at Google Scholar · View at Scopus
  88. H. Gao, W. Shi, and L. B. Freund, “Mechanics of receptor-mediated endocytosis,” Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 27, pp. 9469–9474, 2005. View at Publisher · View at Google Scholar · View at Scopus
  89. K. Yang and Y.-Q. Ma, “Computer simulation of the translocation of nanoparticles with different shapes across a lipid bilayer,” Nature Nanotechnology, vol. 5, no. 8, pp. 579–583, 2010. View at Publisher · View at Google Scholar · View at Scopus
  90. Y. Li, W. Stroberg, T.-R. Lee et al., “Multiscale modeling and uncertainty quantification in nanoparticle-mediated drug/gene delivery,” Computational Mechanics, vol. 53, no. 3, pp. 511–537, 2014. View at Publisher · View at Google Scholar · View at Scopus
  91. Y. Li, Y. Lian, L. T. Zhang et al., “Cell and nanoparticle transport in tumour microvasculature: the role of size, shape and surface functionality of nanoparticles,” Interface Focus, vol. 6, no. 1, Article ID 20150086, 2016. View at Publisher · View at Google Scholar
  92. G. A. Duncan and M. A. Bevan, “Computational design of nanoparticle drug delivery systems for selective targeting,” Nanoscale, vol. 7, no. 37, pp. 15332–15340, 2015. View at Publisher · View at Google Scholar · View at Scopus
  93. J. Liu, G. E. R. Weller, B. Zern et al., “Computational model for nanocarrier binding to endothelium validated using in vivo, in vitro, and atomic force microscopy experiments,” Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 38, pp. 16530–16535, 2010. View at Publisher · View at Google Scholar · View at Scopus
  94. C. Shi, D. Guo, K. Xiao, X. Wang, L. Wang, and J. Luo, “A drug-specific nanocarrier design for efficient anticancer therapy,” Nature Communications, vol. 6, article 7449, 2015. View at Publisher · View at Google Scholar
  95. W. Jiang, J. Luo, and S. Nangia, “Multiscale approach to investigate self-assembly of telodendrimer based nanocarriers for anticancer drug delivery,” Langmuir, vol. 31, no. 14, pp. 4270–4280, 2015. View at Publisher · View at Google Scholar · View at Scopus
  96. Z. Shen, M.-P. Nieh, and Y. Li, “Decorating nanoparticle surface for targeted drug delivery: opportunities and challenges,” Polymers, vol. 8, no. 3, article 83, 2016. View at Publisher · View at Google Scholar
  97. G. Bao, Y. Bazilevs, J. Chung et al., “USNCTAM perspectives on mechanics in medicine,” Journal of The Royal Society Interface, vol. 11, no. 97, Article ID 20140301, 2014. View at Publisher · View at Google Scholar
  98. N. S. Bhise, J. Ribas, V. Manoharan et al., “Organ-on-a-chip platforms for studying drug delivery systems,” Journal of Controlled Release, vol. 190, pp. 82–93, 2014. View at Publisher · View at Google Scholar · View at Scopus