Table of Contents Author Guidelines Submit a Manuscript
Journal of Nanomaterials
Volume 2016, Article ID 1431836, 10 pages
http://dx.doi.org/10.1155/2016/1431836
Research Article

Gold Nanoparticles Promote Proliferation of Human Periodontal Ligament Stem Cells and Have Limited Effects on Cells Differentiation

1Department of Periodontics, School & Hospital of Stomatology, Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai 200072, China
2The Institute for Biomedical Engineering and Nanoscience, School of Medicine, Tongji University, 67 Chifeng Road, Shanghai 200092, China

Received 23 February 2016; Revised 26 May 2016; Accepted 29 June 2016

Academic Editor: Jorge Pérez-Juste

Copyright © 2016 Chen Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. C. Page, S. Offenbacher, H. E. Schroeder, G. J. Seymour, and K. S. Kornman, “Advances in the pathogenesis of periodontitis: summary of developments, clinical implications and future directions,” Periodontology 2000, vol. 14, no. 1, pp. 216–248, 1997. View at Publisher · View at Google Scholar · View at Scopus
  2. B. M. Seo, M. Miura, S. Gronthos et al., “Investigation of multipotent postnatal stem cells from human periodontal ligament,” Lancet, vol. 364, no. 9429, pp. 149–155, 2004. View at Google Scholar
  3. S.-H. Kim, K.-H. Kim, B.-M. Seo et al., “Alveolar bone regeneration by transplantation of periodontal ligament stem cells and bone marrow stem cells in a canine peri-implant defect model: a pilot study,” Journal of Periodontology, vol. 80, no. 11, pp. 1815–1823, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. D. Fang, B.-M. Seo, Y. Liu et al., “Transplantation of mesenchymal stem cells is an optimal approach for plastic surgery,” STEM CELLS, vol. 25, no. 4, pp. 1021–1028, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. J. Xu, W. Wang, Y. Kapila, J. Lotz, and S. Kapila, “Multiple differentiation capacity of STRO-1+/CD146+ PDL mesenchymal progenitor cells,” Stem Cells and Development, vol. 18, no. 3, pp. 487–496, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. V. Vacanti, E. Kong, G. Suzuki, K. Sato, J. M. Canty, and T. Lee, “Phenotypic changes of adult porcine mesenchymal stem cells induced by prolonged passaging in culture,” Journal of Cellular Physiology, vol. 205, no. 2, pp. 194–201, 2005. View at Publisher · View at Google Scholar · View at Scopus
  7. T. Itaya, H. Kagami, K. Okada et al., “Characteristic changes of periodontal ligament-derived cells during passage,” Journal of Periodontal Research, vol. 44, no. 4, pp. 425–433, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. Y. Cheng, J. D. Meyers, A.-M. Broome, M. E. Kenney, J. P. Basilion, and C. Burda, “Deep penetration of a PDT drug into tumors by noncovalent drug-gold nanoparticle conjugates,” Journal of the American Chemical Society, vol. 133, no. 8, pp. 2583–2591, 2011. View at Publisher · View at Google Scholar · View at Scopus
  9. E. Hutter and D. Maysinger, “Gold nanoparticles and quantum dots for bioimaging,” Microscopy Research and Technique, vol. 74, no. 7, pp. 592–604, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. R. Arvizo, R. Bhattacharya, and P. Mukherjee, “Gold nanoparticles: opportunities and challenges in nanomedicine,” Expert Opinion on Drug Delivery, vol. 7, no. 6, pp. 753–763, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. C. Posch, A. Latorre, M. B. Crosby et al., “Detection of GNAQ mutations and reduction of cell viability in uveal melanoma cells with functionalized gold nanoparticles,” Biomedical Microdevices, vol. 17, no. 1, 2015. View at Publisher · View at Google Scholar · View at Scopus
  12. A. M. Alkilany, S. E. Lohse, and C. J. Murphy, “The gold standard: Gold nanoparticle libraries to understand the nano-bio interface,” Accounts of Chemical Research, vol. 46, no. 3, pp. 650–661, 2013. View at Publisher · View at Google Scholar · View at Scopus
  13. R. A. Sperling, P. R. Gil, F. Zhang, M. Zanella, and W. J. Parak, “Biological applications of gold nanoparticles,” Chemical Society Reviews, vol. 37, no. 9, pp. 1896–1908, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. S. Lu, D. Xia, G. Huang, H. Jing, Y. Wang, and H. Gu, “Concentration effect of gold nanoparticles on proliferation of keratinocytes,” Colloids and Surfaces B: Biointerfaces, vol. 81, no. 2, pp. 406–411, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. H.-Y. Gu, Z. Chen, R.-X. Sa et al., “The immobilization of hepatocytes on 24 nm-sized gold colloid for enhanced hepatocytes proliferation,” Biomaterials, vol. 25, no. 17, pp. 3445–3451, 2004. View at Publisher · View at Google Scholar · View at Scopus
  16. Y. Yao, X. Shi, and F. Chen, “The effect of gold nanoparticles on the proliferation and differentiation of murine osteoblast: a study of MC3T3-E1 cells in vitro,” Journal of Nanoscience and Nanotechnology, vol. 14, no. 7, pp. 4851–4857, 2014. View at Publisher · View at Google Scholar · View at Scopus
  17. C. Yi, D. Liu, C.-C. Fong, J. Zhang, and M. Yang, “Gold nanoparticles promote osteogenic differentiation of mesenchymal stem cells through p38 MAPK pathway,” ACS Nano, vol. 4, no. 11, pp. 6439–6448, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. W. Cui, J. Li, Y. Zhang, H. Rong, W. Lu, and L. Jiang, “Effects of aggregation and the surface properties of gold nanoparticles on cytotoxicity and cell growth,” Nanomedicine, vol. 8, no. 1, pp. 46–53, 2012. View at Publisher · View at Google Scholar
  19. F. Feng, K. Akiyama, Y. Liu et al., “Utility of PDL progenitors for in vivo tissue regeneration: a report of 3 cases,” Oral Diseases, vol. 16, no. 1, pp. 20–28, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. T. Akizuki, S. Oda, M. Komaki et al., “Application of periodontal ligament cell sheet for periodontal regeneration: a pilot study in beagle dogs,” Journal of Periodontal Research, vol. 40, no. 3, pp. 245–251, 2005. View at Publisher · View at Google Scholar · View at Scopus
  21. J.-Y. Park, S. H. Jeon, and P.-H. Choung, “Efficacy of periodontal stem cell transplantation in the treatment of advanced periodontitis,” Cell Transplantation, vol. 20, no. 2, pp. 271–285, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. Y. Liu, Y. Zheng, G. Ding et al., “Periodontal ligament stem cell-mediated treatment for periodontitis in miniature swine,” STEM CELLS, vol. 26, no. 4, pp. 1065–1073, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. K. Washio, T. Iwata, M. Mizutani et al., “Assessment of cell sheets derived from human periodontal ligament cells: a pre-clinical study,” Cell and Tissue Research, vol. 341, no. 3, pp. 397–404, 2010. View at Publisher · View at Google Scholar · View at Scopus
  24. D. Liu, C. Yi, D. Zhang, J. Zhang, and M. Yang, “Inhibition of proliferation and differentiation of mesenchymal stem cells by carboxylated carbon nanotubes,” ACS Nano, vol. 4, no. 4, pp. 2185–2195, 2010. View at Publisher · View at Google Scholar · View at Scopus
  25. S. Y. Choi, M. S. Song, P. D. Ryu, A. T. N. Lam, S.-W. Joo, and S. Y. Lee, “Gold nanoparticles promote osteogenic differentiation in human adipose-derived mesenchymal stem cells through the Wnt/β-catenin signaling pathway,” International Journal of Nanomedicine, vol. 10, pp. 4383–4392, 2015. View at Publisher · View at Google Scholar · View at Scopus
  26. D. Zhang, D. Liu, J. Zhang, C. Fong, and M. Yang, “Gold nanoparticles stimulate differentiation and mineralization of primary osteoblasts through the ERK/MAPK signaling pathway,” Materials Science and Engineering: C, vol. 42, pp. 70–77, 2014. View at Publisher · View at Google Scholar · View at Scopus
  27. J. Skillington, L. Choy, and R. Derynck, “Bone morphogenetic protein and retinoic acid signaling cooperate to induce osteoblast differentiation of preadipocytes,” Journal of Cell Biology, vol. 159, no. 1, pp. 135–146, 2002. View at Publisher · View at Google Scholar · View at Scopus
  28. T. Komori, “Requisite roles of Runx2 and Cbfb in skeletal development,” Journal of Bone and Mineral Metabolism, vol. 21, no. 4, pp. 193–197, 2003. View at Google Scholar · View at Scopus
  29. F. Otto, A. P. Thornell, T. Crompton et al., “Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development,” Cell, vol. 89, no. 5, pp. 765–771, 1997. View at Publisher · View at Google Scholar · View at Scopus
  30. J. Li, X. Mou, J. Qiu et al., “Surface charge regulation of osteogenic differentiation of mesenchymal stem cell on polarized ferroelectric crystal substrate,” Advanced Healthcare Materials, vol. 4, no. 7, pp. 998–1003, 2015. View at Publisher · View at Google Scholar · View at Scopus
  31. J. Qiu, D. Li, X. Mou et al., “Effects of graphene quantum dots on the self-renewal and differentiation of mesenchymal stem cells,” Advanced Healthcare Materials, vol. 5, no. 6, pp. 702–710, 2016. View at Publisher · View at Google Scholar · View at Scopus