Effects of End-Terminal Capping on Transthyretin (105–115) Amyloid Protofibrils Using Steered Molecular Dynamics

Figure 6

Stress versus strain graphs and Young’s modulus graphs. Stress-strain curves for each pulling rate (0.001 Å/ps and 0.005 Å/ps) to compute Young’s modulus for both capped and uncapped fibrils. (a) Strain-stress curve calculated from pulling rate of 0.001 Å/ps, (b) strain-stress curve obtained from pulling rate of 0.005 Å/ps, and (c) Young’s modulus of uncapped and capped TTR 105–115 protofibrils from stress-strain curves.

(a)

(b)

(c)