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Journal of Nanomaterials
Volume 2016 (2016), Article ID 2671383, 9 pages
Research Article

Confined Nystatin Polyenes in Nanopore Induce Biologic Ionic Selectivity

1Laboratoire de Nanomédecine, Imagerie et Thérapeutique, EA 4662, Université de Bourgogne-Franche-Comté, Centre Hospitalier Universitaire de Besançon, 16 route de Gray, 25030 Besançon Cedex, France
2CINaM, CNRS UMR 7325, Aix-Marseille University, Campus de Luminy, 13288 Marseille Cedex 9, France
3Institut Européen des Membranes, ENSCM, CNRS UMR 5635, Université de Montpellier, Place Eugène Bataillon, 34095 Montpellier Cedex 5, France

Received 29 March 2016; Accepted 22 May 2016

Academic Editor: David Cornu

Copyright © 2016 Khaoula Boukari et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Antifungal polyenes such as nystatin (or amphotericin B) molecules play an important role in regulating ions permeability through membrane cell. The creation of self-assembled nanopores into the fungal lipid membranes permits the leakage and the selectivity of ions (i.e., blockage of divalent cations) that cause the cell death. These abilities are thus of first interest to promote new biomimetic membranes with improved ionic properties. In the present work, we will use molecular dynamic simulations to interpret recent experimental data that showed the transfer of the nystatin action inside artificial nanopore in terms of ion permeability and selectivity. We will demonstrate that nystatin polyenes can be stabilized in a hydrophobic carbon nanotube, even at high concentration. The high potential interaction between the polyenes and the hydrophobic pore wall ensures the apparition of a hole inside the biomimetic nanopore that changes its intrinsic properties. The probability ratios of cation versus anion show interesting reproducibility of experimental measurements and, to a certain extent, opened the way for transferring biological properties in synthetic membranes.