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Journal of Nanomaterials
Volume 2016, Article ID 2861915, 9 pages
http://dx.doi.org/10.1155/2016/2861915
Research Article

Preparation and Characterization of Baicalein-Loaded Nanoliposomes for Antitumor Therapy

1Department of Biological Engineering, College of Environment & Chemical Engineering, Yanshan University, No. 438 Hebei Street, Qinhuangdao 066004, China
2The First Hospital of Qinhuangdao, No. 258, Wenhua Road, Haigang District, Qinhuangdao, Hebei 066000, China
3The Hospital of Yanshan University, No. 438 Hebei Street, Qinhuangdao 066004, China
4School of Finance, Nankai University, No. 38 Tongshuo Road, Tianjin 300350, China

Received 1 April 2016; Revised 21 May 2016; Accepted 7 June 2016

Academic Editor: Mingqiang Li

Copyright © 2016 Kun Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Baicalein (BAI) is a major constituent of Scutellaria baicalensis Georgi. Previous studies showed that BAI had obvious effects on U14 cervical tumor-bearing mice model and HeLa cells. However, the use of BAI is inconvenient and troublesome, due to its low oral bioavailability. The aim of this study was to develop baicalein-loaded nanoliposomes (BAI-LP) to improve its bioavailability. In this study, BAI-LP was prepared by thin film hydration method. The average size, polydispersity index (PDI), zeta potential and encapsulation efficiency (EE) of the BAI-LP were  nm, ,  mV, and %, respectively. Drug storage stability study showed no significant changes in these values after 4 weeks of storing at 4°C. Additionally, Sulforhodamine B (SRB) experimental results indicated that the BAI-LP could achieve better anti-tumor effects than free BAI. The results of the experiment demonstrated that BAI-LP had a better antitumor effect with a higher inhibition rate of % than free BAI with a inhibition rate of % by using U14 cervical tumor-bearing mice model. In conclusion, the study suggested that BAI-LP would serve as a potent delivery vehicle for BAI in future cancer therapy.