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Journal of Nanomaterials
Volume 2016, Article ID 3038790, 9 pages
Research Article

Computational Modeling of the Effect of Sulci during Tumor Growth and Cerebral Edema

1Department of Neurology, Chongqing General Hospital, Yuzhong, Chongqing 400000, China
2School of Aerospace Engineering, Chongqing University, Shapingba, Chongqing 400017, China
3Institute of High Performance Computing, ASTAR, Singapore 138632
4Department of Mechanical Engineering, Institute of Materials Science, University of Connecticut, Storrs, CT 06269, USA

Received 30 December 2015; Accepted 5 May 2016

Academic Editor: Stefano Bellucci

Copyright © 2016 Dan Peng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This paper aims at studying the effect of sulci structures during tumor growth and cerebral edema in brain tissues. Motivated by the Intracranial Cerebral Pressure (ICP) monitoring during the brain surgery, a computational model has been created to study macroscopic behaviors of brain tissues with local volume expansion introduced by the tumor growth and cerebral edema. To consider the extra-large deformation during the tumor growth, a nonlinear finite element method has been adopted. Numerical simulation results reveal that sulci structures play significant roles in macroscopic volume expansion and maximum stress of brain tissues. Without considering the sulci structures, predictions on the ICP will be dramatically different from those including sulci structure. Therefore, it is strongly suggested that the sulci structure should be included in future studies on the brain modeling for investigating the space-occupying lesions.