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Journal of Nanomaterials
Volume 2016, Article ID 3170248, 8 pages
http://dx.doi.org/10.1155/2016/3170248
Research Article

Biomaterial-Derived Calcium Carbonate Nanoparticles for Enteric Drug Delivery

1Department Materials Science and Engineering, Tuskegee University, Tuskegee, AL 36088, USA
2Department of Pathobiology, Tuskegee University, Tuskegee, AL 36088, USA
3Department of Clinical Sciences, Tuskegee University, Tuskegee, AL 36088, USA
4Department of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Auburn, AL 36849, USA

Received 27 November 2015; Revised 22 February 2016; Accepted 17 March 2016

Academic Editor: Paulo Cesar Morais

Copyright © 2016 Diane Render et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Oral drug delivery systems provide the most convenient, noninvasive, readily acceptable alternatives to parenteral systems. In the current work, eggshell-derived calcium carbonate (CaCO3) nanoparticles were used to develop enteric drug delivery system in the form of tablets. CaCO3 nanoparticles were manufactured using top-down ball-milling method and characterized by X-ray diffractometry (XRD) and transmission electron microscopy (TEM) and loaded with 5-fluorouracil as a model drug. Tablets with varying CaCO3 core and binder compositions were fabricated and coated with Eudragit S100 or Eudragit L100. Suitability for enteric delivery of the tablets was tested by oral administration to rabbits and radiography. Radiograph images showed that the tablet remained in the stomach of the rabbit for up to 3 hours. Further modifications of these biomaterial-derived nanoparticles and the coatings will enable manufacturing of stable formulations for slow or controlled release of pharmaceuticals for enteric delivery.