Acidic Tumor pH-Responsive Nanophotomedicine for Targeted Photodynamic Cancer Therapy

Figure 3

Physicochemical characterization of the pH-NanoPM. (a) UV-Vis absorption spectra of free pheophorbide-a (PPb-a) and pH-PPS. (b) Analysis of the critical aggregate concentration (CAC) of pH-PPS (Inset: fluorescent emission spectra of pyrene in polymer dissolved water). (c) Measurement of singlet oxygen generation of free PPb-a and pH-PPS in DMF with laser irradiation. (d) Particle size distribution of pH-NanoPM particles at different pH values (pH 7.4 and 6.5).

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