Redox-Responsive Nanophotosensitizer Composed of Chlorin e6-Conjugated Dextran for Photodynamic Treatment of Colon Cancer Cells

Figure 3

(a) TEM image and (b) typical particle size distribution of DEX6ss nanoparticles. (c) Ce6 release from DEX6ss nanophotosensitizer in the absence or presence of dextranase. For dextranase treatment, nanoparticles were incubated with dextranase in PBS (0.01 M, pH 7.4) for 3 h at 37°C. (d) The effect of GSH on the Ce6 release from DEX6ss nanoparticles. (e) The effect of GSH concentration on the photophysical properties of DEX6ss nanoparticles. For GSH treatment, 1.0 mg of DEX6ss nanoparticles was incubated with each concentration of GSH in PBS (0.01 M, pH 7.4) for 90 min at 37°C. The presented data was mean ± s.d. from three independent experiments.