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Journal of Nanomaterials
Volume 2016, Article ID 4591634, 8 pages
Review Article

Antiviral Nanodelivery Systems: Current Trends in Acyclovir Administration

1Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia (UPM), 43400 Serdang, Selangor, Malaysia
2Centre for Drug Delivery Research, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia
3Faculty of Pharmacy & Health Sciences, Universiti Kuala Lumpur Royal College of Medicine Perak, No. 3, Jalan Greentown, 30450 Ipoh, Perak, Malaysia

Received 4 April 2016; Revised 19 July 2016; Accepted 25 July 2016

Academic Editor: Changyang Gong

Copyright © 2016 Haniza Hassan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Poor bioavailability of acyclovir in the treatment of viral infections remains one of the major drug delivery concerns of pharmaceutical manufacturers and researchers. Nanoparticulate systems have been exploited with the aim of improving the current pharmacological limitations of acyclovir administration. In fact, nanoparticles do offer many advantages, especially in terms of their physicochemical stability and sustained-release properties. Besides, they are made of biocompatible materials, which are nontoxic to cells. Acyclovir has been a focus since the last decade as one of the low bioavailability drug models loaded in various types of newly synthesized drug delivery vehicles. In this review, compositions and formulations of nanosized acyclovir particles, as well as their stability and pharmacokinetic profile, are discussed in further detail.