Antiviral Nanodelivery Systems: Current Trends in Acyclovir Administration

Table 1

Route of administration of acyclovir and the disadvantages.

Route of administration	Dose	Disadvantages
Oral	1000 mg per day (tablet and suspension)	Low oral bioavailability, high-dose related side effects, that is, nausea, headache, and diarrhoea [8, 15]
Intravenous injection	100 mg/kg	Nephrotoxicity, renal failure, and thrombophlebitis [21, 28]
Topical/transdermal	5% w/w topical ointment, 5 times daily	Difficulty in penetrating epidermal layer, rapid clearance [29]
Ocular	3% w/w ophthalmic ointment, 5 times a day	Poor ocular bioavailability [30]