Polymer Nanoparticle-Based Chemotherapy for Spinal Malignancies

Figure 4

(a) Particle size distribution of IFS-loaded PLGA-dextran (PD/IFS) nanoparticles and TEM image of PD/IFS. (b) The release profile of IFS from the PLGA-dextran nanoparticulate system. The release study was performed in phosphate-buffered saline and acetate-buffered saline. The study was carried out for 96 h. and are the statistical difference between the pH 7.4 and pH 5.5 release media. Apoptosis analysis was detected by Annexin-V/PI staining. Apoptosis of (c) MG63 and (d) Saos-2 cancer cells. The respective cell percentages in early and late apoptosis for different time periods are presented in the bar graph. is the statistical difference in apoptosis between IFS and PD/IFS for both cancer cells.

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