Studies on the Genotoxicity Behavior of Silver Nanoparticles in the Presence of Heavy Metal Cadmium Chloride in Mice

Table 3

The MNPCEs frequencies and PCEs percentage in mice injected i.p. with Ag nanoparticles or/and CaCl₂.

Group	Treatment; (dose mg/kg)	MNPCEs/1000 cells	% PCEs
1	Negative control	5.20 ± 2.17	49.80 ± 1.48
2	Cd(1.6)	47.60 ± 3.36	35.80 ± 2.39
3	Ag(20)	47.20 ± 2.17	41.80 ± 1.30
4	Ag(41)	73.60 ± 6.02	30.60 ± 2.41
5	Ag(82)	94.40 ± 5.94	22.20 ± 3.81
6	Ag(20) + Cd	73.60 ± 6.65	36.20 ± 2.77
7	Ag(41) + Cd	104.60 ± 5.73	25.80 ± 1.92
8	Ag(82) + Cd	144.60 ± 5.73	17.40 ± 1.14
Groups 3, 4, and 5		= 105, < 0.001	= 173, < 0.001
Groups 6, 7, and 8		= 149, < 0.001	= 110, < 0.001

Results were expressed as mean ± SD. Statistically significantly different from the negative control group at < 0.001 and statistically significantly different from the comparable nano-Ag treated group at < 0.01 and < 0.001, respectively, using Student’s -test. One way ANOVA was used to test the effect of different doses of Ag nanoparticles on the tested parameters.