Studies on the Genotoxicity Behavior of Silver Nanoparticles in the Presence of Heavy Metal Cadmium Chloride in Mice
Table 5
The MDA level and CAT activity in bone marrow, testis, and sperms of mice injected i.p. with Ag nanoparticles or/and CaCl2.
Group
Treatment (dose mg/kg)
Bone marrow
Testis
Sperms
MDA level (nmol/g)
CAT activity (U/g)
MDA level (nmol/g)
CAT activity (U/g)
MDA level (nmol/106)
CAT activity (U/106)
1
Negative control
29.76 ± 1.31
8.15 ± 0.52
38.05 ± 1.66
7.01 ± 0.41
2.93 ± 0.16
46.83 ± 2.36
2
Cd(1.6)
49.49 ± 1.80
4.21 ± 0.62
57.77 ± 4.27
3.24 ± 0.29
9.95 ± 0.12
36.09 ± 2.33
3
Ag(20)
47.88 ± 1.71
5.58 ± 0.48
59.17 ± 4.75
4.47 ± 0.38
6.30 ± 0.22
32.79 ± 1.90
4
Ag(41)
60.52 ± 1.12
4.10 ± 0.29
78.04 ± 5.72
2.98 ± 0.29
9.45 ± 0.12
26.50 ± 2.45
5
Ag(82)
89.78 ± 2.48
2.88 ± 0.28
107.03 ± 7.72
2.20 ± 0.25
14.17 ± 0.45
17.51 ± 1.64
6
Ag(20) + Cd
68.93 ± 3.42
4.04 ± 0.37
92.62 ± 2.60
2.57 ± 0.49
8.64 ± 0.30
24.37 ± 1.82
7
Ag(41) + Cd
87.93 ± 1.36
2.95 ± 0.32
116.55 ± 3.44
1.95 ± 0.15
12.40 ± 0.44
13.11 ± 2.19
8
Ag(82) + Cd
116.68 ± 5.82
1.99 ± 0.08
133.43 ± 2.02
1.12 ± 0.16
21.22 ± 2.79
6.86 ± 0.74
Groups 3, 4, and 5
= 1088.7, < 0.001
= 69.7, < 0.001
= 682.8, < 0.001
= 67.7, < 0.001
= 879.1, < 0.001
= 71.8, < 0.001
Groups 6, 7, and 8
= 732.3, < 0.001
= 64.2, < 0.001
= 277.9, < 0.001
= 27.7, < 0.001
= 689.8, < 0.001
= 136.4, < 0.001
Results were expressed as mean ± SD. Statistically significantly different from the negative control group and statistically significantly different from the comparable nano-Ag treated group at < 0.001 using Student’s -test. One way ANOVA was used to test the effect of different doses of Ag nanoparticles on the tested parameters.
