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Journal of Nanomaterials
Volume 2016, Article ID 5284786, 13 pages
Review Article

Solid-State Nanopore-Based DNA Sequencing Technology

1Institute of Microelectronics, Tsinghua University, Beijing 100084, China
2School of Electronic and Information Engineering, Beijing Jiaotong University, Beijing 100044, China

Received 28 March 2016; Accepted 5 May 2016

Academic Editor: William Yu

Copyright © 2016 Zewen Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The solid-state nanopore-based DNA sequencing technology is becoming more and more attractive for its brand new future in gene detection field. The challenges that need to be addressed are diverse: the effective methods to detect base-specific signatures, the control of the nanopore’s size and surface properties, and the modulation of translocation velocity and behavior of the DNA molecules. Among these challenges, the realization of the high-quality nanopores with the help of modern micro/nanofabrication technologies is a crucial one. In this paper, typical technologies applied in the field of solid-state nanopore-based DNA sequencing have been reviewed.