Gold Nanoparticle Mediated Phototherapy for Cancer

Figure 3

TEM micrographs of thin sections of cells that were incubated for 2 h with various AuNP constructs. Magnification of primary images is 6000x; the inset is shown at 28000x. (a) KB cells incubated with mPEG2000−T:AuNP. Occasionally, AuNPs are found adjacent to the cell plasma membrane (arrow), but most are removed by washes during sample preparation. (b) KB cells incubated with F–PEG1500–T:AuNP. Region corresponding to the higher magnification inset is denoted by the arrow which shows significant uptake of nanoparticles throughout the cytoplasm. (c) KB cells incubated with F–PEG–T:AuNP in the presence of excess folic acid. (d) WI-38 cells incubated with F–PEG–T:AuNP. Reprinted with permission from [42]. Copyright (2006) American Chemical Society.

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