Gold Nanoparticle Mediated Phototherapy for Cancer

Figure 4

Efficacy of photothermal therapy demonstrated in the treatment of mice bearing murine melanoma tumors. C57BL/6 mice bearing F10B16 tumors were injected with either PEG-GNRs (200 μL, OD60) or saline (200 μL); the PEG-GNRs were then allowed 48 hrs to circulate within the body, and then half of the mice were exposed to NIR light to maintain ablation temperatures for 6 min (). Their overall survival and tumor volume were tracked throughout the entire length of the study (tumor measurements were taken every 2-3 days). (a) Survival of the mice is plotted against time (days), with day = 0 signifying initial PEG-GNR/saline injection. (b) Tumor volume (mm³) is plotted versus time (days) after initial injection with PEG-GNRs/saline. The data in (a) and (b) were censored [43].

(a)

(b)