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Journal of Nanomaterials
Volume 2016, Article ID 5805034, 7 pages
Research Article

New Collagen-Dextran-Zinc Oxide Composites for Wound Dressing

1Surgery Department, “Carol Davila” University of Medicine and Pharmacy, Dionisie Lupu 37, 020022 Bucharest, Romania
2Surgery Department, “Sfântul Pantelimon” Emergency Clinical Hospital, 340-342 Șoseaua Pantelimon, 021659 Bucharest, Romania
3Faculty of Applied Chemistry and Material Science, Politehnica University of Bucharest, 1-7 Polizu Street, 011061 Bucharest, Romania
4Collagen Department, Leather and Footwear Research Institute, 93 Ion Minulescu Street, 031215 Bucharest, Romania
5Department of Physical and Colloidal Chemistry, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy 6, Traian Vuia Street, 020956 Bucharest, Romania
6Polymer Department, National Institute for Research & Development in Chemistry and Petrochemistry, 202 Splaiul Independenței Boulevard, 060021 Bucharest, Romania

Received 29 September 2015; Accepted 28 December 2015

Academic Editor: Paulo Cesar Morais

Copyright © 2016 Georgeta Păunica-Panea et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The goal of this paper was the design, development, and characterization of some new composites, based on collagen and dextran as natural polymers and zinc oxide as antimicrobial, to be used in wound healing. Collagen hydrogels with various concentrations of dextran and zinc oxide were investigated in terms of rheological analysis. The spongious composites, obtained by freeze-drying of hydrogels, were evaluated by morphology (SEM), water uptake, and biological (enzymatic biodegradation) analysis. All the results were strongly influenced by the nature and concentration of composite components. Based on the performances of the hydrogels, stationary rheometry, porous structure, morphology, and biological behavior, the antimicrobial spongious composite based on collagen and dextran with 50% ZnO were the most promising for future applications in wound dressing and a biomaterial with high potential in skin regeneration.