Nanomechanical Characterization of Amyloid Fibrils Using Single-Molecule Experiments and Computational Simulations

Figure 1

Nanomechanical properties of amyloid fibrils and the role of intermolecular forces in the nanomechanical properties. The elastic modulus of amyloid fibrils is measured in a range of 1 to 10 GPa (blue region in the graph), and this elastic modulus is comparable to that of dragline silk. The nanomechanical properties of amyloid fibrils are measured based on AFM-based single-molecule experiments and simulations such as full-atomistic simulations, backbone-based atomistic simulations, and elastic network model (as shown in figures from lower left panel to lower right panel, resp.). Figures are adopted with permission from [32].