Nanomechanical Characterization of Amyloid Fibrils Using Single-Molecule Experiments and Computational Simulations

Figure 8

Optical tweezer-based stretching experiment of prion fibrils. (a) Three representative force curves for prion fibril when it is extended with a constant pulling speed. Arrows indicate discontinuities in a force-extension curve due to partial unfolding of prion proteins. (b) Fracture mechanism of amyloid fibril made of -helices due to partial unfolding. (c) Fracture mechanism of amyloid fibril made of -sheets due to partial unfolding. Figures are adopted with permission from [35].

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