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Journal of Nanomaterials
Volume 2016 (2016), Article ID 5918462, 11 pages
http://dx.doi.org/10.1155/2016/5918462
Research Article

Preparation, Characterization, and Antitumor Evaluation of Electrospun Resveratrol Loaded Nanofibers

1Department of Neurosurgery, Affiliated Lianyungang Hospital of Xuzhou Medical College, Lianyungang 222000, China
2Department of Neurosurgery, Jiangsu Taizhou People’s Hospital, Taizhou 225300, China
3Department of Oncology, Affiliated Lianyungang Hospital of Xuzhou Medical College, Lianyungang 222000, China
4Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China
5Department of Radiotherapy, The Central Hospital of Xuzhou, Affiliated Hospital of Southeast University, Xuzhou 221009, China

Received 18 January 2016; Accepted 12 April 2016

Academic Editor: Martin Andersson

Copyright © 2016 Hui Zhou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Resveratrol has been reported as a potential antitumor agent for several years. The possible application was greatly hampered by its poor solubility. The current study reported the construction of electrospun Resveratrol loaded nanofibers with methoxypolyethylene glycol-poly(caprolactone) (mPEG-PCL) block copolymers as drug carriers. Characterization studies showed the successful encapsulation of Rsv in the nanofibers with an in vitro sustained release pattern. In vitro XTT assay suggested the superior cytotoxicity of Rsv-NFs with more apoptosis induction on cancer cells. Cells that exposed to Rsv-NFs showed less clonogenic ability when compared to the equivalent dose of free Rsv. In addition, the migration and invasion ability of cells were also significantly lower when treated with Rsv-NFs. In the in vivo study, local implantation of Rsv-NFs greatly increased the growth inhibitory effect compared to free Rsv. Therefore, results from the current study demonstrated a promising way to improve the antitumor effect of Rsv by nanofiber delivery.