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Journal of Nanomaterials
Volume 2016, Article ID 6365295, 9 pages
http://dx.doi.org/10.1155/2016/6365295
Research Article

Niosome Encapsulation of Curcumin: Characterization and Cytotoxic Effect on Ovarian Cancer Cells

1State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa 999078, Macau
2College of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China
3David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
4School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China

Received 29 December 2015; Revised 1 May 2016; Accepted 22 May 2016

Academic Editor: Ruxandra Gref

Copyright © 2016 Ying-Qi Xu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. O. Naksuriya, S. Okonogi, R. M. Schiffelers, and W. E. Hennink, “Curcumin nanoformulations: a review of pharmaceutical properties and preclinical studies and clinical data related to cancer treatment,” Biomaterials, vol. 35, no. 10, pp. 3365–3383, 2014. View at Publisher · View at Google Scholar · View at Scopus
  2. N. G. Vallianou, A. Evangelopoulos, N. Schizas, and C. Kazazis, “Potential anticancer properties and mechanisms of action of curcumin,” Anticancer Research, vol. 35, no. 2, pp. 645–651, 2015. View at Google Scholar · View at Scopus
  3. C. N. Sreekanth, S. V. Bava, E. Sreekumar, and R. J. Anto, “Molecular evidences for the chemosensitizing efficacy of liposomal curcumin in paclitaxel chemotherapy in mouse models of cervical cancer,” Oncogene, vol. 30, no. 28, pp. 3139–3152, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. M. Heger, R. F. van Golen, M. Broekgaarden, and M. C. Michel, “The molecular basis for the pharmacokinetics and pharmacodynamics of curcumin and its metabolites in relation to cancers,” Pharmacological Reviews, vol. 66, no. 1, pp. 222–307, 2014. View at Publisher · View at Google Scholar · View at Scopus
  5. A. Shehzad, F. Wahid, and Y. S. Lee, “Curcumin in cancer chemoprevention: molecular targets, pharmacokinetics, bioavailability, and clinical trials,” Archiv der Pharmazie, vol. 343, no. 9, pp. 489–499, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. N. M. Khalil, T. C. F. D. Nascimento, D. M. Casa et al., “Pharmacokinetics of curcumin-loaded PLGA and PLGA-PEG blend nanoparticles after oral administration in rats,” Colloids and Surfaces B: Biointerfaces, vol. 101, pp. 353–360, 2013. View at Publisher · View at Google Scholar · View at Scopus
  7. P. Anand, A. B. Kunnumakkara, R. A. Newman, and B. B. Aggarwal, “Bioavailability of curcumin: problems and promises,” Molecular Pharmaceutics, vol. 4, no. 6, pp. 807–818, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. S. Barui, S. Saha, G. Mondal, S. Haseena, and A. Chaudhuri, “Simultaneous delivery of doxorubicin and curcumin encapsulated in liposomes of pegylated RGDK-lipopeptide to tumor vasculature,” Biomaterials, vol. 35, no. 5, pp. 1643–1656, 2014. View at Publisher · View at Google Scholar · View at Scopus
  9. X. Zhao, Q. Chen, W. Liu et al., “Codelivery of doxorubicin and curcumin with lipid nanoparticles results in improved efficacy of chemotherapy in liver cancer,” International Journal of Nanomedicine, vol. 10, pp. 257–270, 2015. View at Publisher · View at Google Scholar · View at Scopus
  10. K. Nagahama, Y. Sano, and T. Kumano, “Anticancer drug-based multifunctional nanogels through self-assembly of dextran-curcumin conjugates toward cancer theranostics,” Bioorganic & Medicinal Chemistry Letters, vol. 25, no. 12, pp. 2519–2522, 2015. View at Publisher · View at Google Scholar · View at Scopus
  11. S. P. Singh, M. Sharma, and P. K. Gupta, “Cytotoxicity of curcumin silica nanoparticle complexes conjugated with hyaluronic acid on colon cancer cells,” International Journal of Biological Macromolecules, vol. 74, pp. 162–170, 2015. View at Publisher · View at Google Scholar · View at Scopus
  12. A. Kumar, A. Ahuja, J. Ali, and S. Baboota, “Curcumin loaded nano globules for solubility enhancement: preparation, characterization and ex vivo release study,” Journal of Nanoscience and Nanotechnology, vol. 12, no. 11, pp. 8293–8302, 2012. View at Publisher · View at Google Scholar · View at Scopus
  13. X. Xie, A. M. Xu, S. Leal-Ortiz, Y. Cao, C. C. Garner, and N. A. Melosh, “Nanostraw-electroporation system for highly efficient intracellular delivery and transfection,” ACS Nano, vol. 7, no. 5, pp. 4351–4358, 2013. View at Publisher · View at Google Scholar · View at Scopus
  14. X. Xie, A. M. Xu, M. R. Angle, N. Tayebi, P. Verma, and N. A. Melosh, “Mechanical model of vertical nanowire cell penetration,” Nano Letters, vol. 13, no. 12, pp. 6002–6008, 2013. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Chen, Z. Zhong, W. Tan, S. Wang, and Y. Wang, “Recent advances in nanoparticle formulation of oleanolic acid,” Chinese Medicine, vol. 6, article 20, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. G. Puras, M. Mashal, J. Zárate et al., “A novel cationic niosome formulation for gene delivery to the retina,” Journal of Controlled Release, vol. 174, no. 1, pp. 27–36, 2014. View at Publisher · View at Google Scholar · View at Scopus
  17. R. Rajera, K. Nagpal, S. K. Singh, and D. N. Mishra, “Niosomes: a controlled and novel drug delivery system,” Biological and Pharmaceutical Bulletin, vol. 34, no. 7, pp. 945–953, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. A. Azeem, M. K. Anwer, and S. Talegaonkar, “Niosomes in sustained and targeted drug delivery: some recent advances,” Journal of Drug Targeting, vol. 17, no. 9, pp. 671–689, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. D. Cosco, D. Paolino, R. Muzzalupo et al., “Novel PEG-coated niosomes based on bola-surfactant as drug carriers for 5-fluorouracil,” Biomedical Microdevices, vol. 11, no. 5, pp. 1115–1125, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. G. Abdelbary and N. El-Gendy, “Niosome-encapsulated gentamicin for ophthalmic controlled delivery,” AAPS PharmSciTech, vol. 9, no. 3, pp. 740–747, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. N. Yuksel, Z. S. Bayindir, E. Aksakal, and A. T. Ozcelikay, “In situ niosome forming maltodextrin proniosomes of candesartan cilexetil: in vitro and in vivo evaluations,” International Journal of Biological Macromolecules, vol. 82, pp. 453–463, 2016. View at Publisher · View at Google Scholar · View at Scopus
  22. M. Najlah, K. Hidayat, H. K. Omer et al., “A facile approach to manufacturing non-ionic surfactant nanodipsersions using proniosome technology and high-pressure homogenization,” Journal of Liposome Research, vol. 25, no. 1, pp. 32–37, 2015. View at Publisher · View at Google Scholar
  23. Y.-Z. Zhao, C.-T. Lu, Y. Zhang et al., “Selection of high efficient transdermal lipid vesicle for curcumin skin delivery,” International Journal of Pharmaceutics, vol. 454, no. 1, pp. 302–309, 2013. View at Publisher · View at Google Scholar · View at Scopus
  24. C. F. Chignell, P. Bilski, K. J. Reszka, A. G. Motten, R. H. Sik, and T. A. Dahl, “Spectral and photochemical properties of curcumin,” Photochemistry and Photobiology, vol. 59, no. 3, pp. 295–302, 1994. View at Publisher · View at Google Scholar · View at Scopus
  25. S. Wang, R. Chen, Z. Zhong, Z. Shi, M. Chen, and Y. Wang, “Epigallocatechin-3-gallate potentiates the effect of curcumin in inducing growth inhibition and apoptosis of resistant breast cancer cells,” American Journal of Chinese Medicine, vol. 42, no. 5, pp. 1279–1300, 2014. View at Publisher · View at Google Scholar · View at Scopus
  26. J.-L. Gao, T.-C. He, Y.-B. Li, and Y.-T. Wang, “A traditional Chinese medicine formulation consisting of Rhizoma Corydalis and Rhizoma Curcumae exerts synergistic anti-tumor activity,” Oncology Reports, vol. 22, no. 5, pp. 1077–1083, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. X.-Y. Ke, V. W. Lin Ng, S.-J. Gao, Y. W. Tong, J. L. Hedrick, and Y. Y. Yang, “Co-delivery of thioridazine and doxorubicin using polymeric micelles for targeting both cancer cells and cancer stem cells,” Biomaterials, vol. 35, no. 3, pp. 1096–1108, 2014. View at Publisher · View at Google Scholar · View at Scopus
  28. L. Ouyang, Z. Shi, S. Zhao et al., “Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosis,” Cell Proliferation, vol. 45, no. 6, pp. 487–498, 2012. View at Publisher · View at Google Scholar · View at Scopus
  29. S. Wang, R. Chen, J. Morott, M. A. Repka, Y. Wang, and M. Chen, “MPEG-b-PCL/TPGS mixed micelles for delivery of resveratrol in overcoming resistant breast cancer,” Expert Opinion on Drug Delivery, vol. 12, no. 3, pp. 361–373, 2015. View at Publisher · View at Google Scholar · View at Scopus
  30. Á. H. I. Garces, M. S. F. Dias, E. Paulino, C. G. M. Ferreira, and A. C. De Melo, “Treatment of ovarian cancer beyond chemotherapy: are we hitting the target?” Cancer Chemotherapy and Pharmacology, vol. 75, no. 2, pp. 221–234, 2015. View at Publisher · View at Google Scholar · View at Scopus
  31. S. Carpi, S. Fogli, A. Giannetti et al., “Theranostic properties of a survivin-directed molecular beacon in human melanoma cells,” PLoS ONE, vol. 9, no. 12, article e114588, 2014. View at Publisher · View at Google Scholar · View at Scopus
  32. S. Mondal, S. Ghosh, and S. P. Moulik, “Stability of curcumin in different solvent and solution media: UV–visible and steady-state fluorescence spectral study,” Journal of Photochemistry and Photobiology B: Biology, vol. 158, pp. 212–218, 2016. View at Publisher · View at Google Scholar
  33. A. Karewicz, D. Bielska, B. Gzyl-Malcher, M. Kepczynski, R. Lach, and M. Nowakowska, “Interaction of curcumin with lipid monolayers and liposomal bilayers,” Colloids and Surfaces B: Biointerfaces, vol. 88, no. 1, pp. 231–239, 2011. View at Publisher · View at Google Scholar · View at Scopus
  34. S. Ghanbarzadeh, A. Khorrami, Z. Pourmoazzen, and S. Arami, “Plasma stable, pH-sensitive non-ionic surfactant vesicles simultaneously enhance antiproliferative effect and selectivity of Sirolimus,” Pharmaceutical Development and Technology, vol. 20, no. 3, pp. 279–287, 2015. View at Publisher · View at Google Scholar · View at Scopus
  35. Y.-L. Lin, Y.-K. Liu, N.-M. Tsai et al., “A Lipo-PEG-PEI complex for encapsulating curcumin that enhances its antitumor effects on curcumin-sensitive and curcumin-resistance cells,” Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 8, no. 3, pp. 318–327, 2012. View at Publisher · View at Google Scholar · View at Scopus
  36. C. Li, Y. Zhang, T. T. Su, L. Feng, Y. Long, and Z. Chen, “Silica-coated flexible liposomes as a nanohybrid delivery system for enhanced oral bioavailability of curcumin,” International Journal of Nanomedicine, vol. 7, pp. 5995–6002, 2012. View at Publisher · View at Google Scholar · View at Scopus
  37. F. Re, I. Cambianica, C. Zona et al., “Functionalization of liposomes with ApoE-derived peptides at different density affects cellular uptake and drug transport across a blood-brain barrier model,” Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 7, no. 5, pp. 551–559, 2011. View at Publisher · View at Google Scholar · View at Scopus
  38. A. N. Lazar, S. Mourtas, I. Youssef et al., “Curcumin-conjugated nanoliposomes with high affinity for Aβ deposits: possible applications to Alzheimer disease,” Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 9, no. 5, pp. 712–721, 2013. View at Publisher · View at Google Scholar · View at Scopus