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Journal of Nanomaterials
Volume 2016, Article ID 6709764, 9 pages
http://dx.doi.org/10.1155/2016/6709764
Research Article

Particle Size-Dependent Antibacterial Activity and Murine Cell Cytotoxicity Induced by Graphene Oxide Nanomaterials

1Institute of Quantitative Biology and Medicine, SRMP and RAD-X, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, China
2IBM Thomas J. Watson Research Center, Yorktown Heights, NY 10598, USA
3College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China

Received 31 March 2016; Accepted 11 May 2016

Academic Editor: Shiren Wang

Copyright © 2016 Lin Zhao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. Cha, S. R. Shin, N. Annabi, M. R. Dokmeci, and A. Khademhosseini, “Carbon-based nanomaterials: multifunctional materials for biomedical engineering,” ACS Nano, vol. 7, no. 4, pp. 2891–2897, 2013. View at Publisher · View at Google Scholar · View at Scopus
  2. H. Gong, R. Peng, and Z. Liu, “Carbon nanotubes for biomedical imaging: the recent advances,” Advanced Drug Delivery Reviews, vol. 65, no. 15, pp. 1951–1963, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. X. Zhou and F. Liang, “Application of graphene/graphene oxide in biomedicine and biotechnology,” Current Medicinal Chemistry, vol. 21, no. 7, pp. 855–869, 2014. View at Publisher · View at Google Scholar · View at Scopus
  4. L. Feng and Z. Liu, “Graphene in biomedicine: opportunities and challenges,” Nanomedicine, vol. 6, no. 2, pp. 317–324, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. T. Nezakati, B. G. Cousins, and A. M. Seifalian, “Toxicology of chemically modified graphene-based materials for medical application,” Archives of Toxicology, vol. 88, no. 11, pp. 1987–2012, 2014. View at Publisher · View at Google Scholar · View at Scopus
  6. J. Liu, L. Cui, and D. Losic, “Graphene and graphene oxide as new nanocarriers for drug delivery applications,” Acta Biomaterialia, vol. 9, no. 12, pp. 9243–9257, 2013. View at Publisher · View at Google Scholar · View at Scopus
  7. D.-J. Lim, M. Sim, L. Oh, K. Lim, and H. Park, “Carbon-based drug delivery carriers for cancer therapy,” Archives of Pharmacal Research, vol. 37, no. 1, pp. 43–52, 2014. View at Publisher · View at Google Scholar · View at Scopus
  8. G. S. Martynková and M. Valášková, “Antimicrobial nanocomposites based on natural modified materials: a review of carbons and clays,” Journal of Nanoscience and Nanotechnology, vol. 14, no. 1, pp. 673–693, 2014. View at Publisher · View at Google Scholar · View at Scopus
  9. J. Li, Q. Han, X. Wang et al., “Reduced aggregation and cytotoxicity of amyloid peptides by graphene oxide/gold nanocomposites prepared by pulsed laser ablation in water,” Small, vol. 10, no. 21, pp. 4386–4394, 2014. View at Publisher · View at Google Scholar · View at Scopus
  10. S. Shi, F. Chen, E. B. Ehlerding, and W. Cai, “Surface engineering of graphene-based nanomaterials for biomedical applications,” Bioconjugate Chemistry, vol. 25, no. 9, pp. 1609–1619, 2014. View at Publisher · View at Google Scholar · View at Scopus
  11. W. Hu, C. Peng, W. Luo et al., “Graphene-based antibacterial paper,” ACS Nano, vol. 4, no. 7, pp. 4317–4323, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. S. Gurunathan, J. W. Han, A. Abdal Dayem, V. Eppakayala, and J.-H. Kim, “Oxidative stress-mediated antibacterial activity of graphene oxide and reduced graphene oxide in Pseudomonas aeruginosa,” International Journal of Nanomedicine, vol. 7, pp. 5901–5914, 2012. View at Publisher · View at Google Scholar · View at Scopus
  13. S. Liu, M. Hu, T. H. Zeng et al., “Lateral dimension-dependent antibacterial activity of graphene oxide sheets,” Langmuir, vol. 28, no. 33, pp. 12364–12372, 2012. View at Publisher · View at Google Scholar · View at Scopus
  14. Y. Tu, M. Lv, P. Xiu et al., “Destructive extraction of phospholipids from Escherichia coli membranes by graphene nanosheets,” Nature Nanotechnology, vol. 8, no. 8, pp. 594–601, 2013. View at Publisher · View at Google Scholar · View at Scopus
  15. Y. Chang, S.-T. Yang, J.-H. Liu et al., “In vitro toxicity evaluation of graphene oxide on A549 cells,” Toxicology Letters, vol. 200, no. 3, pp. 201–210, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. L. Agemy, K. N. Sugahara, V. R. Kotamraju et al., “Nanoparticle-induced vascular blockade in human prostate cancer,” Blood, vol. 116, no. 15, pp. 2847–2856, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. Y. Li, H. Yuan, A. Von Dem Bussche et al., “Graphene microsheets enter cells through spontaneous membrane penetration at edge asperities and corner sites,” Proceedings of the National Academy of Sciences of the United States of America, vol. 110, no. 30, pp. 12295–12300, 2013. View at Publisher · View at Google Scholar · View at Scopus
  18. B. Wan, Z.-X. Wang, Q.-Y. Lv et al., “Single-walled carbon nanotubes and graphene oxides induce autophagosome accumulation and lysosome impairment in primarily cultured murine peritoneal macrophages,” Toxicology Letters, vol. 221, no. 2, pp. 118–127, 2013. View at Publisher · View at Google Scholar · View at Scopus
  19. L. De Marzi, L. Ottaviano, F. Perrozzi et al., “Flake size-dependent cyto and genotoxic evaluation of graphene oxide on in vitro A549, CaCo2 and vero cell lines,” Journal of Biological Regulators and Homeostatic Agents, vol. 28, no. 2, pp. 281–289, 2014. View at Google Scholar · View at Scopus
  20. J. Peng, W. Gao, B. K. Gupta et al., “Graphene quantum dots derived from carbon fibers,” Nano Letters, vol. 12, no. 2, pp. 844–849, 2012. View at Publisher · View at Google Scholar · View at Scopus
  21. B. Z. Ristic, M. M. Milenkovic, I. R. Dakic et al., “Photodynamic antibacterial effect of graphene quantum dots,” Biomaterials, vol. 35, no. 15, pp. 4428–4435, 2014. View at Publisher · View at Google Scholar · View at Scopus
  22. M. Nurunnabi, Z. Khatun, K. M. Huh et al., “In vivo biodistribution and toxicology of carboxylated graphene quantum dots,” ACS Nano, vol. 7, no. 8, pp. 6858–6867, 2013. View at Publisher · View at Google Scholar · View at Scopus
  23. S. Stankovich, D. A. Dikin, R. D. Piner et al., “Synthesis of graphene-based nanosheets via chemical reduction of exfoliated graphite oxide,” Carbon, vol. 45, no. 7, pp. 1558–1565, 2007. View at Publisher · View at Google Scholar · View at Scopus
  24. Z.-S. Wu, W. Ren, L. Gao, B. Liu, C. Jiang, and H.-M. Cheng, “Synthesis of high-quality graphene with a pre-determined number of layers,” Carbon, vol. 47, no. 2, pp. 493–499, 2009. View at Publisher · View at Google Scholar · View at Scopus
  25. Y. Liu and D. Y. Kim, “Ultraviolet and blue emitting graphene quantum dots synthesized from carbon nano-onions and their comparison for metal ion sensing,” Chemical Communications, vol. 51, no. 20, pp. 4176–4179, 2015. View at Publisher · View at Google Scholar · View at Scopus
  26. Y. Li, Y. Hu, Y. Zhao et al., “An electrochemical avenue to green-luminescent graphene quantum dots as potential electron-acceptors for photovoltaics,” Advanced Materials, vol. 23, no. 6, pp. 776–780, 2011. View at Publisher · View at Google Scholar · View at Scopus
  27. S. Liu, T. H. Zeng, M. Hofmann et al., “Antibacterial activity of graphite, graphite oxide, graphene oxide, and reduced graphene oxide: membrane and oxidative stress,” ACS Nano, vol. 5, no. 9, pp. 6971–6980, 2011. View at Publisher · View at Google Scholar · View at Scopus
  28. H.-Q. Chen, D. Gao, B. Wang et al., “Graphene oxide as an anaerobic membrane scaffold for the enhancement of B. adolescentis proliferation and antagonistic effects against pathogens E. coli and S. aureus,” Nanotechnology, vol. 25, no. 16, Article ID 165101, 2014. View at Publisher · View at Google Scholar · View at Scopus
  29. O. N. Ruiz, K. A. S. Fernando, B. Wang et al., “Graphene oxide: a nonspecific enhancer of cellular growth,” ACS Nano, vol. 5, no. 10, pp. 8100–8107, 2011. View at Publisher · View at Google Scholar · View at Scopus
  30. J. Chen, H. Peng, X. Wang, F. Shao, Z. Yuan, and H. Han, “Graphene oxide exhibits broad-spectrum antimicrobial activity against bacterial phytopathogens and fungal conidia by intertwining and membrane perturbation,” Nanoscale, vol. 6, no. 3, pp. 1879–1889, 2014. View at Publisher · View at Google Scholar · View at Scopus
  31. J. Li, G. Wang, H. Zhu et al., “Antibacterial activity of large-area monolayer graphene film manipulated by charge transfer,” Scientific Reports, vol. 4, article 4359, 2014. View at Publisher · View at Google Scholar · View at Scopus
  32. Y.-W. Wang, A. Cao, Y. Jiang et al., “Superior antibacterial activity of zinc oxide/graphene oxide composites originating from high zinc concentration localized around bacteria,” ACS Applied Materials and Interfaces, vol. 6, no. 4, pp. 2791–2798, 2014. View at Publisher · View at Google Scholar · View at Scopus
  33. G.-Y. Chen, C.-L. Chen, H.-Y. Tuan et al., “Graphene oxide triggers toll-like receptors/autophagy responses in vitro and inhibits tumor growth in vivo,” Advanced Healthcare Materials, vol. 3, no. 9, pp. 1486–1495, 2014. View at Publisher · View at Google Scholar · View at Scopus
  34. G.-Y. Chen, C.-L. Meng, K.-C. Lin et al., “Graphene oxide as a chemosensitizer: diverted autophagic flux, enhanced nuclear import, elevated necrosis and improved antitumor effects,” Biomaterials, vol. 40, pp. 12–22, 2015. View at Publisher · View at Google Scholar · View at Scopus
  35. Y. Wang, S. Wu, X. Zhao, Z. Su, L. Du, and A. Sui, “In vitro toxicity evaluation of graphene oxide on human RPMI 8226 cells,” Bio-Medical Materials and Engineering, vol. 24, no. 6, pp. 2007–2013, 2014. View at Publisher · View at Google Scholar · View at Scopus
  36. Z. Ding, Z. Zhang, H. Ma, and Y. Chen, “In vitro hemocompatibility and toxic mechanism of graphene oxide on human peripheral blood T Lymphocytes and serum albumin,” ACS Applied Materials and Interfaces, vol. 6, no. 22, pp. 19797–19807, 2014. View at Publisher · View at Google Scholar · View at Scopus